Weight management intervention identifies association of decreased DNA methylation age with improved functional age measures in older adults with obesity

Table 3 Adjusted associations between measures of change in physical function and change in DNA methylation age

Methylation age clocks	Grip strength		Gait speed		Sit-to-stand		Six-minute walk
Methylation age clocks	β (95%CI)	p value	β (95%CI)	p value	β (95%CI)	p value	β (95%CI)	p value
Hannum	− 0.30 (− 0.59 to − 0.01)	0.041	0.02 (0.00 to 0.04)	0.049	0.04 (− 0.17 to 0.24)	0.700	− 1.52 (− 5.06 to 2.02)	0.364
Horvath	− 0.05 (− 0.62 to 0.52)	0.862	0.02 (− 0.01 to 0.06)	0.134	0.19 (− 0.13 to 0.52)	0.215	− 2.61 (− 9.02 to 3.80)	0.389
PhenoAge	− 0.10 (− 0.51 to 0.31)	0.605	0.02 (0.00 to 0.05)	0.039	0.01 (− 0.25 to 0.26)	0.950	0.84 (− 3.58 to 5.25)	0.685

Adjusted models for the association of each DNA methylation-based age clock and each functional measure controlling for chronological age and sex. All effects are in the same relative direction for each methylation age clock and each functional measure, except the association of PhenoAge and the six-min walk

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