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Table 2 Unadjusted associations of age, sex, and change in methylation age clocks with change in grip strength, gait speed, sit-to-stand, and 6-min walk distance functional measures

From: Weight management intervention identifies association of decreased DNA methylation age with improved functional age measures in older adults with obesity

  Grip strength Gait speed Sit-to-stand Six-minute walk
β (95%CI) p value β (95%CI) p value β (95%CI) p value β (95%CI) p value
Age − 0.44 (− 0.77 to 0.11) 0.013 − 0.01 (− 0.03 to 0.01) 0.192 0.22 (0.03 to 0.40) 0.027 − 3.50 (− 6.60 to 0.40) 0.030
Sex
 Female         
 Male 8.12 (2.96 to 13.28) 0.005 0.14 (− 0.15 to 0.43) 0.326 − 4.03 (− 6.97 to 1.08) 0.011 47.14 (− 4.58 to 98.86) 0.071
Methylation age clocks
 Hannum − 0.34 (− 0.89 to 0.21) 0.201 0.02 (− 0.01 to 0.04) 0.184 0.13 (− 0.17 to 0.44) 0.368 − 0.85 (− 5.87 to 4.16) 0.719
 Horvath − 0.15 (− 0.99 to 0.69) 0.704 0.02 (− 0.01 to 0.06) 0.178 0.24 (− 0.19 to 0.68) 0.245 − 2.21 (− 9.92 to 5.50) 0.547
 PhenoAge − 0.45 (− 0.87 to 0.02) 0.041 0.01 (− 0.00 to 0.03) 0.127 0.12 (− 0.14 to 0.37) 0.351 − 2.24 (− 6.26 to 1.78) 0.249