Table 2 Unadjusted associations of age, sex, and change in methylation age clocks with change in grip strength, gait speed, sit-to-stand, and 6-min walk distance functional measures
| Â | Grip strength | Gait speed | Sit-to-stand | Six-minute walk | ||||
|---|---|---|---|---|---|---|---|---|
β (95%CI) | p value | β (95%CI) | p value | β (95%CI) | p value | β (95%CI) | p value | |
Age | − 0.44 (− 0.77 to 0.11) | 0.013 | − 0.01 (− 0.03 to 0.01) | 0.192 | 0.22 (0.03 to 0.40) | 0.027 | − 3.50 (− 6.60 to 0.40) | 0.030 |
Sex | ||||||||
 Female |  |  |  |  |  |  |  |  |
 Male | 8.12 (2.96 to 13.28) | 0.005 | 0.14 (− 0.15 to 0.43) | 0.326 | − 4.03 (− 6.97 to 1.08) | 0.011 | 47.14 (− 4.58 to 98.86) | 0.071 |
Methylation age clocks | ||||||||
 Hannum | − 0.34 (− 0.89 to 0.21) | 0.201 | 0.02 (− 0.01 to 0.04) | 0.184 | 0.13 (− 0.17 to 0.44) | 0.368 | − 0.85 (− 5.87 to 4.16) | 0.719 |
 Horvath | − 0.15 (− 0.99 to 0.69) | 0.704 | 0.02 (− 0.01 to 0.06) | 0.178 | 0.24 (− 0.19 to 0.68) | 0.245 | − 2.21 (− 9.92 to 5.50) | 0.547 |
 PhenoAge | − 0.45 (− 0.87 to 0.02) | 0.041 | 0.01 (− 0.00 to 0.03) | 0.127 | 0.12 (− 0.14 to 0.37) | 0.351 | − 2.24 (− 6.26 to 1.78) | 0.249 |