DNA methylation and cancer incidence: lymphatic–hematopoietic versus solid cancers in the Strong Heart Study

Clinical Epigenetics

Table 7 Differentially Variable Positions for solid cancers

CpG	Chr	Gene	Function	In 450 k	Log Var Ratio	p value	FDR
cg21902846	12	CCDC92	DNA repair and reduction/oxidation reactions	No	0.91	1.22E−11	9.65E−06
cg23070169	2	XIRP2	Associated to Alzheimer’s disease and Down syndrome	No	− 0.64	5.90E−09	0.0022
cg26292116	2	AQP12B	Migration, invasion and proliferation of human breast tumor cells	No	− 0.33	8.44E−09	0.0022
cg13911116	1	MTOR	Its activation promotes tumor growth and metastasis, many MTOR inhibitors have been approved to treat human cancers	Yes	0.28	1.05E−07	0.021
cg21383151	10	TBC1D12	Mutations suggested to be related to bladder cancer	Yes	0.41	1.55E−07	0.023
cg08598861	13	SPRY2	Regulates metastatic potential and differentiation in several cancers	No	− 0.59	1.74E−07	0.023
cg18146737	1	GFI1	Significant role in development of lung cancer and prostate cancer and tumor suppressor gene in colorectal cancer	Yes	0.53	3.37E−07	0.038

Log Var Ratios: Natural log of the ratio of the absolute deviations of cancers versus non-cancers. A Log Var Ratio of log(2) would mean that the variance of one group is twice that of the second group
Models adjusted for age, smoking status (never, former, current), sex (male/female), BMI (kg/m²), cell proportions (CD8T, CD4T, NK, B cells and monocytes), five genetic PCs and study center (Arizona, Oklahoma or Dakota)

ISSN: 1868-7083