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Table 6 Top 15 Differentially Variable Positions for lymphatic–hematopoietic cancers

From: DNA methylation and cancer incidence: lymphatic–hematopoietic versus solid cancers in the Strong Heart Study

CpG

Chr

Gene

Function

In 450 k

Log Var Ratio

p value

FDR

cg03098814

chr6

FAM65B

Inhibits the proliferation of human leukemic T cells

Yes

2.22

1.31E−22

1.03E−16

cg11083276

chr6

FAM65B

Inhibits the proliferation of human leukemic T cells

Yes

1.97

3.61E−21

1.42E−15

cg17090968

chr12

SLC38A1

Sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions

Yes

1.67

1.08E−19

2.85E−14

cg18761994

chr6

FAM65B

Inhibits the proliferation of human leukemic T cells

Yes

2.15

1.78E−19

3.52E−14

cg17757602

chr5

Intergenic

Uncharacterized

Yes

2.02

4.34E−19

6.84E−14

cg11211942

chr15

Intergenic

Uncharacterized

No

1.92

1.26E−17

1.66E−12

cg19936032

chr6

FAM65B

Inhibits the proliferation of human leukemic T cells

Yes

2.04

2.34E−17

2.64E−12

cg02915015

chr6

FAM65B

Inhibits the proliferation of human leukemic T cells

Yes

2.04

1.15E−16

1.13E−11

cg14536812

chr12

Intergenic

Uncharacterized

 

1.84

3.60E−16

3.15E−11

cg08576643

chr6

FAM65B

Inhibits the proliferation of human leukemic T cells

Yes

2.15

4.26E−16

3.36E−11

cg17896599

chr6

FAM65B

Inhibits the proliferation of human leukemic T cells

No

2.15

6.59E−16

4.73E−11

cg01726103

chr6

FAM65B

Inhibits the proliferation of human leukemic T cells

Yes

1.91

8.37E−16

5.50E−11

cg24698979

chr17

ARHGAP23

Increases p53 proto-oncogene’s transactivity

No

1.57

1.09E−15

6.58E−11

cg18368658

chr15

CHST14

Regulates proliferation and neurogenesis of neural progenitor cells

No

1.60

1.62E−15

9.12E−11

cg14216285

chr6

LINC01623

Uncharacterized

Yes

1.79

2.20E−15

1.16E−10

  1. Log Var Ratios: Natural log of the ratio of the absolute deviations of cancers versus non-cancers. A Log Var Ratio of log(2) would mean that the variance of one group is twice that of the second group
  2. Model adjusted for age, smoking status (never, former, current), sex (male/female), BMI (kg/m2), Houseman cell proportions (CD8T, CD4T, NK, B cells and monocytes), five genetic PCs and study center (Arizona, Oklahoma or Dakota)