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Table 6 Top 15 Differentially Variable Positions for lymphatic–hematopoietic cancers

From: DNA methylation and cancer incidence: lymphatic–hematopoietic versus solid cancers in the Strong Heart Study

CpG Chr Gene Function In 450 k Log Var Ratio p value FDR
cg03098814 chr6 FAM65B Inhibits the proliferation of human leukemic T cells Yes 2.22 1.31E−22 1.03E−16
cg11083276 chr6 FAM65B Inhibits the proliferation of human leukemic T cells Yes 1.97 3.61E−21 1.42E−15
cg17090968 chr12 SLC38A1 Sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions Yes 1.67 1.08E−19 2.85E−14
cg18761994 chr6 FAM65B Inhibits the proliferation of human leukemic T cells Yes 2.15 1.78E−19 3.52E−14
cg17757602 chr5 Intergenic Uncharacterized Yes 2.02 4.34E−19 6.84E−14
cg11211942 chr15 Intergenic Uncharacterized No 1.92 1.26E−17 1.66E−12
cg19936032 chr6 FAM65B Inhibits the proliferation of human leukemic T cells Yes 2.04 2.34E−17 2.64E−12
cg02915015 chr6 FAM65B Inhibits the proliferation of human leukemic T cells Yes 2.04 1.15E−16 1.13E−11
cg14536812 chr12 Intergenic Uncharacterized   1.84 3.60E−16 3.15E−11
cg08576643 chr6 FAM65B Inhibits the proliferation of human leukemic T cells Yes 2.15 4.26E−16 3.36E−11
cg17896599 chr6 FAM65B Inhibits the proliferation of human leukemic T cells No 2.15 6.59E−16 4.73E−11
cg01726103 chr6 FAM65B Inhibits the proliferation of human leukemic T cells Yes 1.91 8.37E−16 5.50E−11
cg24698979 chr17 ARHGAP23 Increases p53 proto-oncogene’s transactivity No 1.57 1.09E−15 6.58E−11
cg18368658 chr15 CHST14 Regulates proliferation and neurogenesis of neural progenitor cells No 1.60 1.62E−15 9.12E−11
cg14216285 chr6 LINC01623 Uncharacterized Yes 1.79 2.20E−15 1.16E−10
  1. Log Var Ratios: Natural log of the ratio of the absolute deviations of cancers versus non-cancers. A Log Var Ratio of log(2) would mean that the variance of one group is twice that of the second group
  2. Model adjusted for age, smoking status (never, former, current), sex (male/female), BMI (kg/m2), Houseman cell proportions (CD8T, CD4T, NK, B cells and monocytes), five genetic PCs and study center (Arizona, Oklahoma or Dakota)