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Table 5 Top 15 Differentially Methylated Regions for lymphatic–hematopoietic cancers

From: DNA methylation and cancer incidence: lymphatic–hematopoietic versus solid cancers in the Strong Heart Study

Positions Chr Width N CpGs Stouffer p value Gene Function Overlapping  promoters
24910562: 24912385 chr6 1824 20 2.30E−28 FAM65B Inhibits the proliferation of human leukemic T cells FAM65B-001
32447944: 32455735 chr11 7792 41 2.28E−23 WT1 Oncogene in Acute Myeloid Leukemia WT1-001, WT1-005, WT1-002, WT1-AS-001, WT1-AS-201, WT1-AS-005, WT1-009, WT1-004, WT1-AS-003, WT1-AS-004, WT1-AS-002, WT1-AS-006, WT1-006, WT1-003
31159558: 31160393 chr16 836 6 5.77E−16 PRSS36 Serine protease (cleaves peptide bonds in proteins) PRSS36
73565440: 73565966 chr10 527 5 4.22E−09 CDH23 Encodes calcium dependent cell–cell adhesion glycoproteins. Might be associated with breast cancer CDH23, SNORA71, SNORA17
159869223: 159870915 chr1 1693 10 1.28E−08 CFAP45 Uncharacterized function snoU13, Y_RNA, SCARNA16, SNORD112, SNORA63, U3, SNORA51, SNORA25, SNORD59, SCARNA20, SNORA67, U6, SNORA70, SNORA77, SNORA26, SNORA72, U8, SNORA31, SNORA40, CCDC19, hsa-mir-4259, ACA64, SNORD78, snoU109, SNORD60, SNORD116
52995053: 52995634 chr12 582 7 1.56E−08 KRT72 Structural integrity of epithelial cells RP11-641A6.2, KRT72, snoMe28S-Am2634
30476089: 30477270 chr22 1182 15 3.62E−08 HORMAD2 Meiotic prophase quality control. Associated with lung cancer HORMAD2, CTA-85E5.10
149112318: 149113196 chr7 879 6 5.09E−08 ZNF777 Zinc finger protein. Nucleic acid binding None
42951711: 42952369 chr5 659 4 1.21E−07 LOC648987 Uncharacterized function SNORA27, SNORA68, RPS23P5, SNORA57, SNORA76, 7SK, SNORD45
157164556: 157165335 chr1 780 5 2.26E−07 ETV3 Transcriptional repressor associated to dendritic cell tumor snoU13, Y_RNA, SCARNA16, SNORD112, SNORA63, U3, SNORA51, SNORA25, SNORD59, SCARNA20, SNORA67, U6, SNORA70, SNORA77, SNORA26, SNORA72, U8, SNORA31, SNORA40, SNORD64, ACA64, SNORD78, snoU109, SNORD60, SNORD116
49726500: 49727110 chr12 611 5 2.28E−07 C1QL4 Tumor necrosis factor C1QL4, snoMe28S-Am2634
375248: 375830 chr10 583 5 2.83E-07 DIP2C Mutations in breast and lung cancer (potential diagnosis target) DIP2C
157182707: 157187341 chr2 4635 22 3.92E−07 NR4A2 Transcription factor. Potential therapeutic target for gastrointestinal cancer 5S_rRNA, SNORA4, SNORD11, SNORD51, SNORA41, SCARNA6, SNORD39, SNORA75, ACA59, SNORA48, NR4A2, SNORA43, SNORA1, Vault
76803270: 76803925 chr10 656 5 6.10E−07 DUPD1 Dual specificity phosphatase SNORA71, SNORA17, DUPD1
64253534: 64253818 chr3 285 6 1.19E−06 PRICKLE2 Related to WNT signaling pathways U7, SNORD77, SNORA33, SNORA81, SNORD66, SNORD2, SNORD5, SNORD38, SNORD63, PRICKLE2, Metazoa_SRP, SNORA18
  1. Model adjusted for age, smoking status (never, former, current), sex (male/female), BMI (kg/m2) Houseman cell proportions (CD8T, CD4T, NK, B cells and monocytes), five genetic PCs and study center (Arizona, Oklahoma or Dakota)