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Table 5 Top 15 Differentially Methylated Regions for lymphatic–hematopoietic cancers

From: DNA methylation and cancer incidence: lymphatic–hematopoietic versus solid cancers in the Strong Heart Study

Positions

Chr

Width

N CpGs

Stouffer p value

Gene

Function

Overlapping  promoters

24910562: 24912385

chr6

1824

20

2.30E−28

FAM65B

Inhibits the proliferation of human leukemic T cells

FAM65B-001

32447944: 32455735

chr11

7792

41

2.28E−23

WT1

Oncogene in Acute Myeloid Leukemia

WT1-001, WT1-005, WT1-002, WT1-AS-001, WT1-AS-201, WT1-AS-005, WT1-009, WT1-004, WT1-AS-003, WT1-AS-004, WT1-AS-002, WT1-AS-006, WT1-006, WT1-003

31159558: 31160393

chr16

836

6

5.77E−16

PRSS36

Serine protease (cleaves peptide bonds in proteins)

PRSS36

73565440: 73565966

chr10

527

5

4.22E−09

CDH23

Encodes calcium dependent cell–cell adhesion glycoproteins. Might be associated with breast cancer

CDH23, SNORA71, SNORA17

159869223: 159870915

chr1

1693

10

1.28E−08

CFAP45

Uncharacterized function

snoU13, Y_RNA, SCARNA16, SNORD112, SNORA63, U3, SNORA51, SNORA25, SNORD59, SCARNA20, SNORA67, U6, SNORA70, SNORA77, SNORA26, SNORA72, U8, SNORA31, SNORA40, CCDC19, hsa-mir-4259, ACA64, SNORD78, snoU109, SNORD60, SNORD116

52995053: 52995634

chr12

582

7

1.56E−08

KRT72

Structural integrity of epithelial cells

RP11-641A6.2, KRT72, snoMe28S-Am2634

30476089: 30477270

chr22

1182

15

3.62E−08

HORMAD2

Meiotic prophase quality control. Associated with lung cancer

HORMAD2, CTA-85E5.10

149112318: 149113196

chr7

879

6

5.09E−08

ZNF777

Zinc finger protein. Nucleic acid binding

None

42951711: 42952369

chr5

659

4

1.21E−07

LOC648987

Uncharacterized function

SNORA27, SNORA68, RPS23P5, SNORA57, SNORA76, 7SK, SNORD45

157164556: 157165335

chr1

780

5

2.26E−07

ETV3

Transcriptional repressor associated to dendritic cell tumor

snoU13, Y_RNA, SCARNA16, SNORD112, SNORA63, U3, SNORA51, SNORA25, SNORD59, SCARNA20, SNORA67, U6, SNORA70, SNORA77, SNORA26, SNORA72, U8, SNORA31, SNORA40, SNORD64, ACA64, SNORD78, snoU109, SNORD60, SNORD116

49726500: 49727110

chr12

611

5

2.28E−07

C1QL4

Tumor necrosis factor

C1QL4, snoMe28S-Am2634

375248: 375830

chr10

583

5

2.83E-07

DIP2C

Mutations in breast and lung cancer (potential diagnosis target)

DIP2C

157182707: 157187341

chr2

4635

22

3.92E−07

NR4A2

Transcription factor. Potential therapeutic target for gastrointestinal cancer

5S_rRNA, SNORA4, SNORD11, SNORD51, SNORA41, SCARNA6, SNORD39, SNORA75, ACA59, SNORA48, NR4A2, SNORA43, SNORA1, Vault

76803270: 76803925

chr10

656

5

6.10E−07

DUPD1

Dual specificity phosphatase

SNORA71, SNORA17, DUPD1

64253534: 64253818

chr3

285

6

1.19E−06

PRICKLE2

Related to WNT signaling pathways

U7, SNORD77, SNORA33, SNORA81, SNORD66, SNORD2, SNORD5, SNORD38, SNORD63, PRICKLE2, Metazoa_SRP, SNORA18

  1. Model adjusted for age, smoking status (never, former, current), sex (male/female), BMI (kg/m2) Houseman cell proportions (CD8T, CD4T, NK, B cells and monocytes), five genetic PCs and study center (Arizona, Oklahoma or Dakota)