Clinical evaluation of Bladder CARE, a new epigenetic test for bladder cancer detection in urine samples

Clinical Epigenetics

Table 1 Performance characteristics of different non-invasive BC tests

Test name	Principle	Sensitivity%	Specificity%
Bladder CARE	Multiplex MSRE-qPCR	94*	93*
BTA stat	Immunoassay	61 [23]	78 [23]
Cxbladder	RT-qPCR	91 [24]	Not reported
EpiCheck	Multiplex MSRE-qPCR	63 [25, 26]	86 [25, 26]
ImmunoCyt	Immunocytochemical assay	62 [23]	79 [23]
NMP22 BladderChek	Immunoassay	58 [23]	85 [23]
UroMark	Targeted bisulfite sequencing	98 [21]	97 [21]
UroVysion	Fluorescence in situ hybridization (FISH)	72 [27]	83 [27]
Cytology		48 [23]	86 [23]
Cystoscopy (blue light)		92 [28]	48 [28]
Cystoscopy (white light)		81 [28]	49 [28]

Test type and performance characteristics of several non-invasive BC tests are summarized and compared to cytology and cystoscopy techniques
^*Performance of Bladder CARE is based on the results reported in this manuscript

ISSN: 1868-7083