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Table 1 Performance characteristics of different non-invasive BC tests

From: Clinical evaluation of Bladder CARE, a new epigenetic test for bladder cancer detection in urine samples

Test name Principle Sensitivity% Specificity%
Bladder CARE Multiplex MSRE-qPCR 94* 93*
BTA stat Immunoassay 61 [23] 78 [23]
Cxbladder RT-qPCR 91 [24] Not reported
EpiCheck Multiplex MSRE-qPCR 63 [25, 26] 86 [25, 26]
ImmunoCyt Immunocytochemical assay 62 [23] 79 [23]
NMP22 BladderChek Immunoassay 58 [23] 85 [23]
UroMark Targeted bisulfite sequencing 98 [21] 97 [21]
UroVysion Fluorescence in situ hybridization (FISH) 72 [27] 83 [27]
Cytology   48 [23] 86 [23]
Cystoscopy (blue light)   92 [28] 48 [28]
Cystoscopy (white light)   81 [28] 49 [28]
  1. Test type and performance characteristics of several non-invasive BC tests are summarized and compared to cytology and cystoscopy techniques
  2. *Performance of Bladder CARE is based on the results reported in this manuscript