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Table 3 Odds of T2D for six CpG sites and one DMR identified in the meta-EWAS of T2D

From: DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts

CpG

Chr

Gene

Genomic Feature

Main model

BMI-adjusted model

Variation in T2D (%)a

OR

95% CI

P

OR

95% CI

P

cg19693031

1

TXNIP

3′UTR

0.93

(0.89,0.98)

1.10E−02

0.94

(0.89,0.99)

3.00E−02

2.0

cg00144180

2

HDAC4

5′UTR

1.08

(1.01,1.16)

2.40E−02

1.08

(1.00,1.17)

4.00E−02

2.9

cg00574958

11

CPT1A

5′UTR

0.79

(0.62,1.00)

5.13E−02

0.83

(0.65,1.04)

1.10E−01

1.3

cg16765088

15

SYNM

Intergenic

0.93

(0.88,0.99)

1.64E−02

0.93

(0.88,0.99)

2.00E−02

3.3

cg24704287

19

MIR23A

Intergenic

0.95

(0.89,1.02)

1.57E−01

0.96

(0.89,1.03)

2.20E−01

1.3

cg06500161

21

ABCG1

Body

1.13

(1.06,1.21)

3.77E−04

1.1

(1.03,1.18)

1.00E−02

5.7

DMR

11

CPT1A

Intron

0.65

(0.45,0.92)

1.42E−02

0.7

(0.48,1.00)

5.00E−02

1.1

  1. Highlighted in bold are associations with p < 0.05. Associations were conducted in a subsample of ALSPAC (n = 1050, N = 48 T2D cases). Main model was adjusted for age, sex, SVs, 6-Houseman cells and smoking, and a second model was additionally adjusted for BMI
  2. aVariation calculated using the Nagelkerke’s R2 statistic derived from an unadjusted logistic regression