CpG site | Gene | ALSPAC (N = 1050) | LBC1936 (N = 915) | RSIII-1 (N = 728) | RS-Bios (N = 735) | Meta-analysis (N = 3428) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta | P | Beta | P | Beta | P | Beta | P | Beta | SE | P | Direction | I2 | Phet | ||
cg19693031b | TXNIP | − 0.022 | 5.93E−03 | − 0.026 | 3.88E−06 | − 0.019 | 1.86E−05 | − 0.015 | 1.27E−03 | − 0.019 | 2.59E−03 | 8.75E−14 | − − − − | 0.00 | 4.55E−01 |
cg06500161a,b | ABCG1 | 0.026 | 2.68E−04 | 0.024 | 5.18E−08 | 0.010 | 5.06E−03 | 0.008 | 9.90E−03 | 0.013 | 1.92E−03 | 2.34E−11 | + + + + | 77.70 | 3.72E−03 |
cg16765088 | SYNM | − 0.021 | 8.47E−03 | − 0.014 | 4.20E−04 | − 0.009 | 2.20E−02 | − 0.009 | 5.43E−05 | − 0.011 | 1.75E−03 | 5.50E−10 | − − − − | 0.00 | 4.29E−01 |
cg00574958a,b | CPT1A | − 0.005 | 3.60E−02 | − 0.008 | 6.68E−05 | − 0.018 | 6.19E−06 | − 0.004 | 1.51E−01 | − 0.007 | 1.25E−03 | 1.20E−08 | − − − − | 72.20 | 1.29E−02 |
cg24704287 | MIR23A | − 0.009 | 1.41E−01 | − 0.012 | 1.20E−02 | − 0.012 | 6.71E−04 | − 0.011 | 8.31E−04 | − 0.011 | 1.97E−03 | 2.34E−08 | − − − − | 0.00 | 9.68E−01 |
cg00144180 | HDAC4 | 0.012 | 5.61E−02 | 0.013 | 5.88E−04 | 0.019 | 3.67E−04 | 0.008 | 3.94E−02 | 0.012 | 2.23E−03 | 5.64E−08 | + + + + | 4.70 | 3.69E−01 |
cg04567334 | CDH23 | − 0.001 | 7.81E−01 | − 0.005 | 5.49E−02 | − 0.007 | 1.89E−03 | − 0.007 | 9.38E−05 | − 0.006 | 1.18E−03 | 1.67E−07 | − − − − | 0.00 | 6.70E−01 |
cg10584271 | ITIH1 | − 0.007 | 3.58E−01 | − 0.019 | 8.08E−04 | − 0.017 | 2.92E−04 | − 0.010 | 2.43E−02 | − 0.014 | 2.63E−03 | 1.73E−07 | − − − − | 5.60 | 3.65E−01 |
cg26270261 | KRT4 | − 0.004 | 4.35E−01 | − 0.011 | 8.41E−05 | − 0.007 | 1.37E−02 | − 0.004 | 8.07E−03 | − 0.006 | 1.24E−03 | 5.68E−07 | − − − − | 31.10 | 2.25E−01 |
cg16575444 | CX3CL1 | 0.001 | 7.90E−01 | − 0.004 | 1.29E−01 | − 0.006 | 7.51E−03 | − 0.007 | 2.90E−05 | − 0.006 | 1.22E−03 | 6.83E−07 | + − − − | 0.00 | 4.54E−01 |
cg24512093 | ROBO1 | − 0.018 | 3.57E−02 | − 0.009 | 7.87E−02 | − 0.004 | 3.28E−01 | − 0.011 | 1.06E−05 | − 0.010 | 1.92E−03 | 7.16E−07 | − − − − | 16.50 | 3.09E−01 |
cg11983038a | Intergenic | − 0.027 | 8.44E−04 | − 0.003 | 7.69E−01 | − 0.007 | 2.44E−01 | − 0.025 | 7.05E−06 | − 0.017 | 3.38E−03 | 7.23E−07 | − − − − | 65.10 | 3.53E−02 |
cg25136644 | ATG9B | − 0.010 | 8.33E−02 | − 0.007 | 4.43E−02 | − 0.005 | 2.25E−02 | − 0.012 | 4.52E−05 | − 0.007 | 1.44E−03 | 7.27E−07 | − − − − | 34.80 | 2.04E−01 |
cg20812370a | PBX1 | − 0.017 | 2.53E−02 | − 0.017 | 9.03E−05 | − 0.003 | 1.51E−01 | − 0.007 | 5.11E−04 | − 0.007 | 1.34E−03 | 7.40E−07 | − − − − | 70.70 | 1.67E−02 |
cg24686009 | RAP1B | − 0.002 | 3.16E−04 | − 0.001 | 2.82E−02 | − 0.003 | 3.34E−03 | 0.000 | 8.43E−01 | − 0.002 | 3.83E−04 | 1.19E−06 | − − − + | 0.20 | 3.91E−01 |
cg11024682b | SREBF1 | 0.007 | 1.07E−01 | 0.007 | 1.95E−02 | 0.011 | 1.08E−03 | 0.006 | 1.48E−02 | 0.008 | 1.59E−03 | 1.33E−06 | + + + + | 0.00 | 6.94E−01 |
cg06114363d | ZNF683 | − 0.016 | 2.27E−02 | − 0.012 | 5.08E−04 | − 0.008 | 7.40E−03 | ? | ? | − 0.010 | 2.16E−03 | 1.37E−06 | − − − ? | 0.00 | 5.30E−01 |
cg01963618 | LOC285768 | − 0.010 | 1.17E−01 | − 0.011 | 5.08E−03 | − 0.007 | 4.91E−02 | − 0.007 | 1.77E−03 | − 0.008 | 1.58E−03 | 1.55E−06 | − − − − | 0.00 | 8.01E−01 |
cg22680424 | HCCA2 | 0.009 | 2.38E−01 | 0.013 | 6.20E−04 | 0.007 | 3.18E−02 | 0.006 | 8.16E−03 | 0.008 | 1.63E−03 | 2.16E−06 | + + + + | 0.00 | 4.92E−01 |
cg19876302 | Intergenic | − 0.020 | 2.27E−02 | − 0.007 | 1.06E−01 | − 0.010 | 2.21E−03 | − 0.006 | 5.08E−03 | − 0.008 | 1.70E−03 | 2.22E−06 | − − − − | 0.00 | 4.30E−01 |
cg08857797 | VPS25 | 0.002 | 8.08E−01 | 0.012 | 1.09E−02 | 0.008 | 6.17E−03 | 0.008 | 2.53E−03 | 0.009 | 1.84E−03 | 2.28E−06 | + + + + | 0.00 | 8.13E−01 |
cg27374726 | Intergenic | − 0.006 | 2.35E−01 | − 0.015 | 5.06E−04 | − 0.004 | 2.66E−01 | − 0.011 | 3.93E−04 | − 0.009 | 1.83E−03 | 2.32E−06 | − − − − | 42.40 | 1.57E−01 |
cg09185884 | KCTD2 | 0.011 | 2.94E−02 | 0.015 | 6.40E−02 | 0.013 | 4.18E−02 | 0.010 | 1.28E−03 | 0.011 | 2.31E−03 | 2.33E−06 | + + + + | 0.00 | 9.19E−01 |
cg27115863 | Intergenic | − 0.023 | 3.50E−03 | − 0.006 | 2.40E−01 | − 0.010 | 2.27E−02 | − 0.012 | 1.23E−03 | − 0.011 | 2.31E−03 | 2.41E−06 | − − − − | 13.40 | 3.25E−01 |
cg24795867 | WNT5B | − 0.007 | 3.59E−01 | − 0.002 | 6.13E−01 | − 0.002 | 3.62E−01 | − 0.008 | 5.51E−07 | − 0.006 | 1.29E−03 | 2.47E−06 | − − − − | 43.20 | 1.52E−01 |
cg08945443 | ZMYND17 | − 0.006 | 3.92E−01 | 0.009 | 1.63E−01 | 0.015 | 6.67E−04 | 0.012 | 2.08E−04 | 0.010 | 2.23E−03 | 2.64E−06 | − + + + | 51.70 | 1.02E−01 |
cg06039489 | C20orf26 | 0.008 | 3.03E−01 | 0.028 | 2.22E−03 | 0.010 | 1.39E−01 | 0.018 | 3.43E−04 | 0.016 | 3.35E−03 | 2.71E−06 | + + + + | 16.80 | 3.08E−01 |
cg08570691 | RPL13AP5 | − 0.012 | 7.78E−02 | − 0.010 | 3.93E−03 | − 0.014 | 3.64E−04 | − 0.004 | 8.95E−02 | − 0.008 | 1.76E−03 | 2.78E−06 | − − − − | 42.60 | 1.56E−01 |
cg12593793 | Intergenic | − 0.012 | 2.93E−02 | − 0.011 | 1.17E−03 | − 0.014 | 4.03E−04 | − 0.003 | 2.27E−01 | − 0.008 | 1.65E−03 | 2.90E−06 | − − − − | 60.50 | 5.54E−02 |
cg27037013 | Intergenic | − 0.027 | 2.39E−02 | − 0.025 | 7.68E−04 | − 0.019 | 2.20E−03 | − 0.007 | 1.41E−01 | − 0.015 | 3.22E−03 | 2.90E−06 | − − − − | 51.90 | 1.01E−01 |
cg07212837 | Intergenic | 0.003 | 5.45E−01 | 0.008 | 6.22E−03 | 0.007 | 2.72E−02 | 0.006 | 1.93E−03 | 0.006 | 1.38E−03 | 3.28E−06 | + + + + | 0.00 | 8.43E−01 |
cg16192197 | Intergenic | 0.007 | 4.31E−01 | 0.005 | 3.38E−01 | 0.009 | 1.75E−02 | 0.013 | 5.29E−05 | 0.010 | 2.06E−03 | 3.71E−06 | + + + + | 0.00 | 5.03E−01 |
cg15560632 | LRCH4 | − 0.001 | 7.24E−03 | − 0.001 | 3.40E−03 | − 0.002 | 1.02E−02 | − 0.001 | 1.62E−01 | − 0.001 | 2.04E−04 | 3.83E−06 | − − − − | 3.50 | 3.75E−01 |
cg14003143a | SGK2 | − 0.021 | 5.65E−04 | − 0.007 | 1.49E−02 | − 0.007 | 8.21E−03 | − 0.004 | 3.85E−02 | − 0.006 | 1.27E−03 | 4.12E−06 | − − − − | 62.60 | 4.54E−02 |
cg20154947 | PLEC1 | − 0.002 | 3.91E−04 | − 0.002 | 1.49E−03 | − 0.002 | 1.48E−01 | 0.000 | 7.36E−01 | − 0.002 | 4.09E−04 | 4.34E−06 | − − − − | 23.40 | 2.71E−01 |
cg25741837 | SMYD5 | 0.022 | 4.86E−03 | 0.007 | 9.85E−02 | 0.009 | 2.33E−02 | 0.009 | 4.74E−03 | 0.009 | 2.01E−03 | 4.76E−06 | + + + + | 0.00 | 3.96E−01 |
cg26766064 | MIR657 | − 0.014 | 8.56E−02 | − 0.010 | 7.14E−03 | − 0.008 | 1.59E−02 | − 0.005 | 6.10E−03 | − 0.007 | 1.43E−03 | 5.17E−06 | − − − − | 0.00 | 4.12E−01 |
cg25536676 | DHCR24 | − 0.007 | 2.52E−01 | − 0.012 | 1.48E−03 | − 0.014 | 3.67E−04 | − 0.004 | 8.16E−02 | − 0.008 | 1.68E−03 | 5.39E−06 | − − − − | 54.80 | 8.42E−02 |
cg11376147b | SLC43A1 | − 0.008 | 1.03E−02 | − 0.004 | 5.34E−02 | − 0.007 | 1.94E−02 | − 0.005 | 1.45E−02 | − 0.006 | 1.27E−03 | 5.43E−06 | − − − − | 0.00 | 7.64E−01 |
cg20316538 | RUFY4 | − 0.008 | 1.15E−01 | − 0.007 | 7.53E−03 | − 0.007 | 1.39E−02 | − 0.004 | 1.06E−02 | − 0.005 | 1.16E−03 | 6.11E−06 | − − − − | 0.00 | 6.05E−01 |
cg18181703c | SOCS3 | − 0.024 | 7.42E−03 | − 0.011 | 2.08E−02 | − 0.016 | 2.85E−04 | − 0.004 | 2.26E−01 | − 0.010 | 2.31E−03 | 6.20E−06 | − − − − | 56.50 | 7.52E−02 |
cg11851382 | PPAP2B | − 0.012 | 2.34E−02 | − 0.012 | 3.79E−03 | − 0.005 | 2.13E−01 | − 0.006 | 5.87E−03 | − 0.008 | 1.69E−03 | 6.42E−06 | − − − − | 0.00 | 4.91E−01 |
cg00162348 | RNF40 | − 0.002 | 1.79E−04 | − 0.001 | 5.06E−02 | − 0.003 | 4.86E−02 | − 0.001 | 5.94E−01 | − 0.002 | 4.23E−04 | 6.64E−06 | − − − − | 0.00 | 6.00E−01 |
cg07184465 | SPZ1 | − 0.012 | 3.83E−02 | − 0.006 | 6.66E−02 | − 0.011 | 1.40E−04 | − 0.004 | 1.03E−01 | − 0.007 | 1.55E−03 | 7.18E−06 | − − − − | 38.20 | 1.83E−01 |
cg14284506 | Intergenic | − 0.009 | 8.08E−04 | − 0.005 | 1.01E−03 | − 0.003 | 2.51E−01 | − 0.002 | 5.00E−01 | − 0.005 | 1.08E−03 | 7.31E−06 | − − − − | 21.90 | 2.79E−01 |
cg11252555a | RPL13AP5 | − 0.013 | 4.69E−02 | − 0.010 | 3.55E−03 | − 0.015 | 1.85E−04 | − 0.003 | 2.03E−01 | − 0.008 | 1.73E−03 | 7.44E−06 | − − − − | 63.30 | 4.25E−02 |
cg10082515 | Intergenic | − 0.022 | 3.20E−03 | − 0.006 | 5.79E−01 | − 0.010 | 7.04E−02 | − 0.014 | 1.56E−03 | − 0.013 | 3.00E−03 | 7.46E−06 | − − − − | 0.00 | 5.05E−01 |
cg00896068 | Intergenic | − 0.003 | 6.50E−01 | − 0.011 | 7.96E−03 | − 0.004 | 3.10E−01 | − 0.009 | 1.79E−04 | − 0.008 | 1.74E−03 | 7.58E−06 | − − − − | 0.00 | 4.82E−01 |
cg01577083 | Intergenic | − 0.018 | 4.64E−03 | − 0.012 | 4.99E−02 | − 0.008 | 5.13E−02 | − 0.012 | 1.44E−02 | − 0.011 | 2.54E−03 | 7.93E−06 | − − − − | 0.00 | 6.21E−01 |
cg00320980 | Intergenic | − 0.006 | 3.44E−01 | − 0.007 | 8.21E−02 | − 0.012 | 2.75E−03 | − 0.010 | 4.24E−03 | − 0.009 | 2.09E−03 | 7.97E−06 | − − − − | 0.00 | 7.44E−01 |
cg20231084 | Intergenic | − 0.011 | 1.12E−01 | − 0.008 | 1.78E−02 | − 0.005 | 6.20E−02 | − 0.006 | 2.49E−03 | − 0.006 | 1.39E−03 | 8.36E−06 | − − − − | 0.00 | 7.96E−01 |
cg15832662 | RTN3 | − 0.010 | 1.70E−01 | − 0.012 | 6.91E−03 | − 0.012 | 5.16E−02 | − 0.008 | 5.65E−03 | − 0.009 | 2.08E−03 | 8.45E−06 | − − − − | 0.00 | 8.29E−01 |
cg13178597 | RGS17 | − 0.018 | 1.41E−02 | − 0.005 | 4.64E−01 | − 0.009 | 2.36E−02 | − 0.011 | 1.60E−03 | − 0.010 | 2.27E−03 | 8.57E−06 | − − − − | 0.00 | 5.80E−01 |
cg20116935 | SEMA3B | − 0.015 | 3.85E−03 | − 0.005 | 5.45E−02 | − 0.006 | 6.60E−02 | − 0.005 | 6.69E−03 | − 0.006 | 1.38E−03 | 8.89E−06 | − − − − | 4.80 | 3.69E−01 |
cg00989505 | MIR299 | 0.003 | 5.16E−01 | − 0.004 | 1.00E−01 | − 0.006 | 4.00E−04 | − 0.004 | 6.73E−03 | − 0.004 | 9.41E−04 | 9.33E−06 | + − − − | 14.80 | 3.18E−01 |
cg07068382 | MTCH1 | 0.000 | 9.91E−01 | 0.020 | 1.38E−04 | 0.011 | 1.32E−02 | 0.007 | 3.60E−02 | 0.010 | 2.37E−03 | 9.46E−06 | − + + + | 46.70 | 1.31E−01 |
cg14476101b | PHGDH | − 0.021 | 4.05E−02 | 0.000 | 9.46E−01 | − 0.021 | 2.41E−04 | − 0.017 | 4.72E−03 | − 0.015 | 3.36E−03 | 9.46E−06 | − − − − | 52.00 | 1.00E−01 |
cg20456243 | SPEG | − 0.015 | 6.49E−02 | − 0.004 | 2.74E−01 | − 0.010 | 3.31E−03 | − 0.007 | 3.41E−03 | − 0.007 | 1.65E−03 | 9.99E−06 | − − − − | 0.00 | 4.90E−01 |