Association of expression of epigenetic molecular factors with DNA methylation and sensitivity to chemotherapeutic agents in cancer cell lines

Table 4 Correlations of average epigenome methylation with GMD expression in individual cancer categories satisfying p_FDR < 0.15

Cancer category	GMD	Spearman ρ	p_FDR	Sample size
CLLE	CSNK1E	0.8750	0.0306*	15
LAML	CBX2	0.8018	0.0306*	19
PAAD	CBX1	0.6606	0.0538	27
COAD/READ	SIRT1	0.5506	0.0538	43
COAD/READ	SUZ12	0.5471	0.0538	43
COAD/READ	HELLS	0.5388	0.0538	43
CLLE	CBX2	0.8036	0.0733	15
NSCLC	UHRF1	0.3563	0.0766	96
LAML	MECP2	0.7158	0.0845	19
PAAD	EZH2	0.6172	0.0845	27
GLIOMA	TET3	0.5439	0.0845	36
COAD/READ	SUV39H2	0.5115	0.0845	43
CLLE	DNMT3B	0.7750	0.0886	15
CLLE	DNMT1	0.7643	0.1029	15
LIHC	CBX1	0.7279	0.1029	17
GLIOMA	PHC2	− 0.5228	0.1119	36
CLLE	UHRF1	0.7393	0.1455	15
MATBCL	UHRF2	0.5291	0.1455	33
NSCLC	MBD1	− 0.3169	0.1455	96

An asterisk (*) indicates statistically significant associations with p_FDR < 0.05

ISSN: 1868-7083