Table 3 GMDs with the highest numbers of strong correlations between their expression and methylation levels of target probes and gene regions within individual cancer categories
Cancer type | GMD | Positive correlations | Negative correlations |
|---|---|---|---|
GMD correlations with ≥ 5 individual probes | |||
NSCLC | MGMT | 25 | 0 |
CLLE | UHRF1 | 15 | 0 |
NSCLC | DNMT3A | 12 | 0 |
NSCLC | PHC2 | 2 | 9 |
NSCLC | CBX2 | 8 | 2 |
BREAST | EHMT1 | 6 | 0 |
THCA | CBX2 | 6 | 0 |
CLLE | SUV39H2 | 5 | 0 |
COAD/READ | APOBEC1 | 0 | 34 |
CLLE | ZBTB38 | 0 | 25 |
BREAST | SMUG1 | 2 | 5 |
NSCLC | SETDB1 | 0 | 7 |
GMD correlations with > 100 gene regions | |||
CLLE | UHRF1 | 1320 | 2 |
CLLE | CBX2 | 687 | 0 |
CLLE | PHC2 | 651 | 0 |
CLLE | CSNK1E | 536 | 0 |
CLLE | EHMT2 | 392 | 0 |
COAD/READ | SIRT1 | 359 | 0 |
BREAST | EHMT1 | 268 | 39 |
CLLE | SUV39H2 | 293 | 1 |
SCLC | DNMT1 | 261 | 1 |
STAD | TET1 | 239 | 0 |
CLLE | IDH2 | 165 | 0 |
CLLE | DNMT1 | 154 | 0 |
SARCOMA | IDH2 | 139 | 5 |
STAD | CBX1 | 135 | 1 |
COAD/READ | SUZ12 | 126 | 1 |
CLLE | DNMT3B | 120 | 0 |
GLIOMA | TET3 | 113 | 0 |
COAD/READ | UHRF1 | 111 | 0 |
CLLE | EZH2 | 106 | 0 |
BREAST | BCAT1 | 89 | 63 |
CLLE | ZBTB38 | 0 | 869 |
COAD/READ | APOBEC1 | 5 | 766 |
BREAST | SMUG1 | 34 | 273 |
BREAST | TDG | 50 | 195 |
BREAST | APOBEC3C | 22 | 97 |