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Table 3 GMDs with the highest numbers of strong correlations between their expression and methylation levels of target probes and gene regions within individual cancer categories

From: Association of expression of epigenetic molecular factors with DNA methylation and sensitivity to chemotherapeutic agents in cancer cell lines

Cancer type GMD Positive correlations Negative correlations
GMD correlations with ≥ 5 individual probes
NSCLC MGMT 25 0
CLLE UHRF1 15 0
NSCLC DNMT3A 12 0
NSCLC PHC2 2 9
NSCLC CBX2 8 2
BREAST EHMT1 6 0
THCA CBX2 6 0
CLLE SUV39H2 5 0
COAD/READ APOBEC1 0 34
CLLE ZBTB38 0 25
BREAST SMUG1 2 5
NSCLC SETDB1 0 7
GMD correlations with > 100 gene regions
CLLE UHRF1 1320 2
CLLE CBX2 687 0
CLLE PHC2 651 0
CLLE CSNK1E 536 0
CLLE EHMT2 392 0
COAD/READ SIRT1 359 0
BREAST EHMT1 268 39
CLLE SUV39H2 293 1
SCLC DNMT1 261 1
STAD TET1 239 0
CLLE IDH2 165 0
CLLE DNMT1 154 0
SARCOMA IDH2 139 5
STAD CBX1 135 1
COAD/READ SUZ12 126 1
CLLE DNMT3B 120 0
GLIOMA TET3 113 0
COAD/READ UHRF1 111 0
CLLE EZH2 106 0
BREAST BCAT1 89 63
CLLE ZBTB38 0 869
COAD/READ APOBEC1 5 766
BREAST SMUG1 34 273
BREAST TDG 50 195
BREAST APOBEC3C 22 97
  1. Listed are the counts of correlations satisfying p < 6.039 × 10–10 and Spearman |ρ| > 0.5 for individual probes and pFDR < 0.05 and Spearman |ρ| > 0.5 for gene regions