Fig. 2
From: FK228 sensitizes radioresistant small cell lung cancer cells to radiation
FK228 sensitizes SCLC cells to radiation. a The anti-proliferative effect of radiation in a panel of SCLC cell lines. SCLC cell lines were treated with 4 Gy of X-ray irradiation. Growth inhibition was determined by CellTiter-Glo Luminescent assay at 72 h after irradiation. b Survival curves (top panel) and survival fractions (bottom panel) of FK228 at different radiation doses. Quantification of survival fraction was shown mean ± SEM. c FK228 combined with radiation dramatically suppresses the ability of colony formation in radioresistant SCLC cell lines. Left panels show the representative images of colony formation assay; right panels show the quantification of colony upon treatment with DMSO control, FK228, radiation or the combination. *p < 0.05, **p < 0.01, ***p < 0.001; no, no significance