Fig. 2
From: SMYD3: a regulator of epigenetic and signaling pathways in cancer
Main mechanisms of drug-mediated SMYD3 inhibition. a SMYD3 protein graphic illustrating two critical binding areas for inhibitors, the SAM- (S-adenosyl-methionine), and substrate-binding pockets. b Substrate-competitive inhibition. BCI-121 and BAY-6035 bind to the substrate-binding pocket of SMYD3. c SAM-competitive inhibition. GSK2807 binds to the SAM-binding pocket and inhibits binding of SAM to SMYD3. d Mixed-type inhibition. EPZ031686, EPZ030456, and EPZ028862 inhibit both the substrate- and SAM-binding pockets of SMYD3