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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects

Fig. 2

Novel smoking-associated DNA methylation signals in SLAMF7. a coMET plot [33] describing the genomic region of epigenome-wide association between smoking and SLAMF7 methylation (top panel) showing the two smoking-DMPs cg00045592 and cg04009575, along with functional annotation of the region (middle panel) where broad ChromHMM regions are displayed using UCSC genome browser color schemes, and pattern of co-methylation at the 12 CpG sites in the EPIC array annotated to SLAMF7 (bottom panel). b Boxplot showing a comparison of DNA methylation levels at cg00045592 between smokers, former smokers and never smokers in the combined TwinsUK, NCDS, NSHD, BCS70 data set. c Boxplot showing a comparison of DNA methylation levels at cg04009575 between smokers, former smokers and never smokers in the Strong Heart Study

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