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Fig. 7 | Clinical Epigenetics

Fig. 7

From: Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression

Fig. 7

Identification of an alternative transcript of Oxtr that is associated with KLW2 genotype. a RNA-seq evidence of a novel alternative transcript of Oxtr originating in the third intron. Reads providing evidence of this transcript are highlighted in yellow. b Expression of the alternative transcript is not impacted by sex (males: n = 13, females: n = 13; Wilcoxon rank-sum test, W = 63, p = 0.44). c Expression of the alternative transcript is not impacted by handling condition (MAN0: n = 14, MAN1: n = 12; Wilcoxon rank-sum test, W = 82, p = 0.85). d Expression of the alternative transcript is associated with the A allele of KLW2 (A carrier: n = 12, G/G: n = 14; Wilcoxon rank sum test, W = 156, p = 3.85e-7). e Expression of the alternative transcript is positively correlated with expression of the main Oxtr transcript in animals carrying the A allele of KLW2 (2 way KLW2 genotype x Oxtr main transcript expression ANOVA, interaction effect F(1,21) = 23.723, p = 8.14e-5, adjusted R2 = 0.734; A carriers: Spearman’s ρ = 0.81, p = 0.0024; G/G: Spearman’s ρ = 0.48, p = 0.097)

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