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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression

Fig. 6

Genetic x epigenetic interactions affecting Oxtr expression. a Genotype at KLW1 does not impact Oxtr expression (A carriers: n = 14; G/G: n = 12; Welch two sample t test, t23.9 = -0.06, p = 0.95). Animals are grouped by the presence of minor allele (A) because of low abundance of A/A homozygotes. The DNA sequence surrounding KLW1 is shown in the below graph. b Genotype at KLW2 does not impact Oxtr expression (A carriers: n = 12; G/G: n = 14; Welch two sample t test, t20.4 = -0.89, p = 0.38). Animals are grouped by presence of minor allele (A) because of low abundance of A/A homozygotes. The DNA sequence surrounding KLW2 is shown in the below graph. c The relationship between MT2 DNA methylation (represented by community 3 standardized network score) and Oxtr expression does not differ between KLW1 genotypes (A carriers: n = 14, R = -0.49, p = 0.076; G/G: n = 12, R = -0.51, p = 0.091), but D) does differ between KLW2 genotypes (A carriers: n = 12, R = -0.84, p = 0.00065; G/G: n = 14, R = -0.35, p = 0.22) and E) NT213739 genotypes (C/T: n = 9, R = -0.17, p = 0.66; T/T: n = 17, R = -0.61, p = 0.01)

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