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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression

Fig. 4

Genetic and epigenetic features of exon 3 do not control Oxtr expression. a Offspring receiving less parental care (MAN0) have decreased DNA methylation across exon 3 in the nucleus accumbens (13 male–female sibling pairs; MAN0: n = 7 males, 7 females; MAN1: n = 6 males, 6 females; mixed effect model with fixed effect of handling condition and random effects of individual and CpG site; Type II Wald F test F(1,24) = 8.386, p = 0.018. CpG sites are numbered according to Additional file 1: Fig S1B. b DNA methylation in exon 3 is not robustly associated with Oxtr expression in prairie vole nucleus accumbens. Spearman’s rank correlation was used to determine correlation. CpG 36, the only site that has a significant correlation with Oxtr expression (not corrected for multiple comparisons) is shown in black. Sites that do not have a significant correlation with Oxtr expression are in gray. Spearman’s rho and p values for each site are in Additional file 1: Table S3

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