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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner

Fig. 6

NOX4 regulated H3K4me3 methylation through promoting the inactivation of KDM5A. a The expression of H3K4ME3 and the quantification of signal intensities after NOX4 knockdown with or without knockdown of siKDM5A. Bar = 20 μm. b The protein expression of histone methylation markers after NOX4 knockdown with or without knockdown of siKDM5A. c The mRNA level of SNAIL1 in HPAC and Panc1 cells after NOX4 knockdown with or without knockdown of siKDM5A. d The migration and invasion of HPAC and Panc1 cells after knockdown of siKDM5A. e ChIP-qPCR analysis of H3K4me3 for SNAIL1 in HPAC and Panc1 cells after NOX4 knockdown with or without knockdown of siKDM5A. ns, no significance, *p < 0.05, **p < 0.01, ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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