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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner

Fig. 4

Hypoxia-induced NOX4 activation was independent of HIF1A, but dependent on TGFB1. a The representative IHC sections and statistical analysis of NOX4 and HIF1A expression in PC tissues. b The protein expression of NOX4 and HIF1A after knockdown of HIF1A and treatment of 1% O2. c The secretion of TGFB1 by HPAC cells after hypoxia was determined by ELISA. d The protein expression of NOX4 after treatment with TGFB1 neutralizing antibody and/or 1%O2 in HPAC cells. e The protein expression of NOX4 after treatment with TGFB1 in time and concentration gradient in HPAC cells. *p < 0.05, **p < 0.01, ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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