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Fig. 5 | Clinical Epigenetics

Fig. 5

From: 5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells

Fig. 5

UPLC N-glycan changes are associated with the mRNA expression levels of glycosyltransferases. a Histogram representation of the relative expression of both the MGAT5 and ST3GAL4 glycosyltransferases and enzymes involved in the sugar nucleotide donor pathway (MPI, TSTA3 and GMDS) in 5-AZA-dC treated compared to the untreated controls. b A comparison of the expression of the two transcription factors, GATA2 and 3 with the glycosyltransferases, ST3GAL4 and MGAT5. The relative expression level of each gene was calculated according to the ddCt method normalised to TBP. Each condition was undertaken as one biological replicate with 2–3 technical replicates. Spearman’s correlation was used

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