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Table 5 Cox regression analyses of variables for overall survival in non-M3 AML patients

From: Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia

Variables Univariate analysis Multivariate analysis
Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
LEP methylation 1.496 (0.979–2.287) 0.063 1.584 (1.018–2.464) 0.041
Age 2.015 (1.362–2.981) 0.000 1.802 (1.203–2.700) 0.004
WBC 1.933 (1.302–2.870) 0.001 1.796 (1.209–2.668) 0.004
Cytogenetic risks 1.525 (1.173–1.982) 0.002 1.388 (1.050–1.834) 0.021
NPM1 mutations 0.646 (0.310–1.346) 0.243   
FLT3-ITD mutations 0.905 (0.416–1.967) 0.801   
C-KIT mutations 0.757 (0.239–2.402) 0.636   
N/K-RAS mutations 0.944 (0.470–1.895) 0.871   
DNMT3A mutations 1.420 (0.653–3.088) 0.377   
U2AF1 mutations 2.293 (0.709–7.413) 0.166   
IDH1/2 mutations 0.722 (0.226–2.309) 0.583   
SRSF2 mutations 1.892 (0.685–5.222) 0.218   
SETBP1 mutations 0.576 (0.080–4.152) 0.584   
  1. Variables including LEP methylation (hypermethylation vs. non-hypermethylation), age (≤ 60 vs. > 60 years), WBC (≥ 30 × 109 vs. < 30 × 109/L), and gene mutations (mutant vs. wild-type). Multivariate analysis includes variables with P < 0.100 in univariate analysis
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