|
Variables
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
Hazard ratio (95% CI)
|
P value
|
Hazard ratio (95% CI)
|
P value
|
|---|
|
LEP methylation
|
1.496 (0.979–2.287)
|
0.063
|
1.584 (1.018–2.464)
|
0.041
|
|
Age
|
2.015 (1.362–2.981)
|
0.000
|
1.802 (1.203–2.700)
|
0.004
|
|
WBC
|
1.933 (1.302–2.870)
|
0.001
|
1.796 (1.209–2.668)
|
0.004
|
|
Cytogenetic risks
|
1.525 (1.173–1.982)
|
0.002
|
1.388 (1.050–1.834)
|
0.021
|
|
NPM1 mutations
|
0.646 (0.310–1.346)
|
0.243
| | |
|
FLT3-ITD mutations
|
0.905 (0.416–1.967)
|
0.801
| | |
|
C-KIT mutations
|
0.757 (0.239–2.402)
|
0.636
| | |
|
N/K-RAS mutations
|
0.944 (0.470–1.895)
|
0.871
| | |
|
DNMT3A mutations
|
1.420 (0.653–3.088)
|
0.377
| | |
|
U2AF1 mutations
|
2.293 (0.709–7.413)
|
0.166
| | |
|
IDH1/2 mutations
|
0.722 (0.226–2.309)
|
0.583
| | |
|
SRSF2 mutations
|
1.892 (0.685–5.222)
|
0.218
| | |
|
SETBP1 mutations
|
0.576 (0.080–4.152)
|
0.584
| | |
- Variables including LEP methylation (hypermethylation vs. non-hypermethylation), age (≤ 60 vs. > 60 years), WBC (≥ 30 × 109 vs. < 30 × 109/L), and gene mutations (mutant vs. wild-type). Multivariate analysis includes variables with P < 0.100 in univariate analysis
