Skip to main content

Table 5 Cox regression analyses of variables for overall survival in non-M3 AML patients

From: Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia

Variables

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

LEP methylation

1.496 (0.979–2.287)

0.063

1.584 (1.018–2.464)

0.041

Age

2.015 (1.362–2.981)

0.000

1.802 (1.203–2.700)

0.004

WBC

1.933 (1.302–2.870)

0.001

1.796 (1.209–2.668)

0.004

Cytogenetic risks

1.525 (1.173–1.982)

0.002

1.388 (1.050–1.834)

0.021

NPM1 mutations

0.646 (0.310–1.346)

0.243

  

FLT3-ITD mutations

0.905 (0.416–1.967)

0.801

  

C-KIT mutations

0.757 (0.239–2.402)

0.636

  

N/K-RAS mutations

0.944 (0.470–1.895)

0.871

  

DNMT3A mutations

1.420 (0.653–3.088)

0.377

  

U2AF1 mutations

2.293 (0.709–7.413)

0.166

  

IDH1/2 mutations

0.722 (0.226–2.309)

0.583

  

SRSF2 mutations

1.892 (0.685–5.222)

0.218

  

SETBP1 mutations

0.576 (0.080–4.152)

0.584

  
  1. Variables including LEP methylation (hypermethylation vs. non-hypermethylation), age (≤ 60 vs. > 60 years), WBC (≥ 30 × 109 vs. < 30 × 109/L), and gene mutations (mutant vs. wild-type). Multivariate analysis includes variables with P < 0.100 in univariate analysis