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Table 4 Cox regression analyses of variables for overall survival in AML patients

From: Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia

Variables

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

LEP methylation

1.639 (1.104–2.435)

0.014

1.515 (0.996–2.304)

0.052

Age

2.690 (1.839–3.933)

0.000

2.033 (1.364–3.031)

0.000

WBC

2.358 (1.613–3.447)

0.000

1.980 (1.350–2.903)

0.000

Cytogenetic risks

1.723 (1.386–2.143)

0.000

1.427 (1.112–1.831)

0.005

NPM1 mutations

0.769 (0.371–1.594)

0.479

  

FLT3-ITD mutations

0.858 (0.396–1.860)

0.699

  

C-KIT mutations

0.870 (0.319–2.375)

0.785

  

N/K-RAS mutations

1.097 (0.549–2.192)

0.793

  

DNMT3A mutations

1.615 (0.745–3.500)

0.225

  

U2AF1 mutations

2.482 (0.771–7.995)

0.128

  

IDH1/2 mutations

0.844 (0.265–2.684)

0.774

  

SRSF2 mutations

2.113 (0.767–5.820)

0.148

  

SETBP1 mutations

0.657 (0.091–4.729)

0.677

  
  1. Variables including LEP methylation (hypermethylation vs. non-hypermethylation), age (≤ 60 vs. > 60 years), WBC (≥ 30 × 109 vs. < 30 × 109 /L), and gene mutations (mutant vs. wild-type). Multivariate analysis includes variables with P < 0.100 in univariate analysis
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Clinical Epigenetics

ISSN: 1868-7083

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