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Table 4 Cox regression analyses of variables for overall survival in AML patients

From: Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia

Variables Univariate analysis Multivariate analysis
Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
LEP methylation 1.639 (1.104–2.435) 0.014 1.515 (0.996–2.304) 0.052
Age 2.690 (1.839–3.933) 0.000 2.033 (1.364–3.031) 0.000
WBC 2.358 (1.613–3.447) 0.000 1.980 (1.350–2.903) 0.000
Cytogenetic risks 1.723 (1.386–2.143) 0.000 1.427 (1.112–1.831) 0.005
NPM1 mutations 0.769 (0.371–1.594) 0.479   
FLT3-ITD mutations 0.858 (0.396–1.860) 0.699   
C-KIT mutations 0.870 (0.319–2.375) 0.785   
N/K-RAS mutations 1.097 (0.549–2.192) 0.793   
DNMT3A mutations 1.615 (0.745–3.500) 0.225   
U2AF1 mutations 2.482 (0.771–7.995) 0.128   
IDH1/2 mutations 0.844 (0.265–2.684) 0.774   
SRSF2 mutations 2.113 (0.767–5.820) 0.148   
SETBP1 mutations 0.657 (0.091–4.729) 0.677   
  1. Variables including LEP methylation (hypermethylation vs. non-hypermethylation), age (≤ 60 vs. > 60 years), WBC (≥ 30 × 109 vs. < 30 × 109 /L), and gene mutations (mutant vs. wild-type). Multivariate analysis includes variables with P < 0.100 in univariate analysis
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