Fig. 6
From: Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia
a Circos plot including driver mutation associations among 65 AML patients. Colors are determined by functional pathway of each given gene. b Patterns of association of mutations among studied patients. MLL mutations also include MLL-MLLT3 and MLL-MLLT4 fusion gene lesions while KMT2A represents KMT2A specific gene lesions only. c Patterns of association of mutational pathway abnormalities among studied patients. d Patterns of association of mutations among ASXL1, BCOR, U2AF1, SRSF2 patients with significantly lower H3K27me3 levels than wildtype. Filled areas represent significant positive (red) or negative (blue) co-occurrence p < 0.05. Color and size indicate of filled area indicates Pearson’s correlation coefficient