Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins

Wang, Lijie; Mohammadnejad, Afsaneh; Li, Weilong; Lund, Jesper; Li, Shuxia; Clemmensen, Signe; Timofeeva, Maria; Soerensen, Mette; Mengel-From, Jonas; Christensen, Kaare; Hjelmborg, Jacob; Tan, Qihua

doi:10.1186/s13148-021-01009-5

Table 2 Heritability estimation at top 13 CpG sites of MGMT showing high heritability at two time points

From: Genetic and environmental determinants of O⁶-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins

CpG site	Year 1997			Year 2007
CpG site	a²	c²	e²	a²	c²	e²
cg09993319^c	0.9985 (0.9973–0.9997)	0.0000 (0.0000–0.0000)	0.0015 (0.0003–0.0027)	0.9961 (0.9931–0.9991)	0.0000 (0.0000–0.0000)	0.0039 (0.0009–0.0069)
cg27275103^c	0.9923 (0.9857–0.9990)	0.0000 (0.0000–0.0000)	0.0077 (0.0010–0.0143)	0.9853 (0.9740–0.9966)	0.0000 (0.0000–0.0000)	0.0147 (0.0034–0.0260)
cg16255663^c	0.9816 (0.9674–0.9958)	0.0000 (0.0000–0.0000)	0.0184 (0.0042–0.0326)	0.9760 (0.9575–0.9946)	0.0000 (0.0000–0.0000)	0.0240 (0.0054–0.0425)
cg17686260^c	0.9810 (0.9661–0.9960)	0.0000 (0.0000–0.0000)	0.0190 (0.0040–0.0339)	0.9874 (0.9776–0.9972)	0.0000 (0.0000–0.0000)	0.0126 (0.0028–0.0224)
cg26201213^c	0.7158 (0.4997–0.9320)	0.0000 (0.0000–0.0000)	0.2842 (0.0680–0.5003)	0.5978 (0.3148–0.8807)	0.0000 (0.0000–0.0000)	0.4022 (0.1193–0.6852)
cg06952798^c	0.5428 (0.2146–0.8711)	0.0000 (0.0000–0.0000)	0.4572 (0.1289–0.7854)	0.5033 (0.0980–0.9086)	0.0000 (0.0000–0.0000)	0.4967 (0.0914–0.9020)
cg27483317^a	0.7057 (0.4854–0.9261)	0.0000 (0.0000–0.0000)	0.2943 (0.0739–0.5146)	0.0000 (0.0000–0.0000)	0.5641 (0.2106–0.9176)	0.4359 (0.0824–0.7894)
cg09757049^a	0.5358 (0.1247–0.9469)	0.0000 (0.0000–0.0000)	0.4642 (0.0531–0.8753)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg10215460^a	0.5175 (0.2026–0.8324)	0.0000 (0.0000–0.0000)	0.4825 (0.1676–0.7974)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg14668152^a	0.5124 (0.2010–0.8237)	0.0000 (0.0000–0.0000)	0.4876 (0.1763–0.7990)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg14273607^a	0.4750 (0.0226–0.9275)	0.0000 (0.0000–0.0000)	0.5250 (0.0725–0.9774)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg06179303^a	0.4279 (0.0041–0.8516)	0.0000 (0.0000–0.0000)	0.5721 (0.1484–0.9959)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg02792401^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.5255 (0.0644–0.9866)	0.0000 (0.0000–0.0000)	0.4745 (0.0134–0.9356)

^a^,bRepresent significant CpG sites showing high heritability with 0 not included in the 2.5–97.5% confidence intervals in 1997 and 2007, respectively
^cRepresents overlapped significant CpG sites between 1997 and 2007

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