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Table 2 Heritability estimation at top 13 CpG sites of MGMT showing high heritability at two time points

From: Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins

CpG site Year 1997 Year 2007
a2 c2 e2 a2 c2 e2
cg09993319c 0.9985 (0.9973–0.9997) 0.0000 (0.0000–0.0000) 0.0015 (0.0003–0.0027) 0.9961 (0.9931–0.9991) 0.0000 (0.0000–0.0000) 0.0039 (0.0009–0.0069)
cg27275103c 0.9923 (0.9857–0.9990) 0.0000 (0.0000–0.0000) 0.0077 (0.0010–0.0143) 0.9853 (0.9740–0.9966) 0.0000 (0.0000–0.0000) 0.0147 (0.0034–0.0260)
cg16255663c 0.9816 (0.9674–0.9958) 0.0000 (0.0000–0.0000) 0.0184 (0.0042–0.0326) 0.9760 (0.9575–0.9946) 0.0000 (0.0000–0.0000) 0.0240 (0.0054–0.0425)
cg17686260c 0.9810 (0.9661–0.9960) 0.0000 (0.0000–0.0000) 0.0190 (0.0040–0.0339) 0.9874 (0.9776–0.9972) 0.0000 (0.0000–0.0000) 0.0126 (0.0028–0.0224)
cg26201213c 0.7158 (0.4997–0.9320) 0.0000 (0.0000–0.0000) 0.2842 (0.0680–0.5003) 0.5978 (0.3148–0.8807) 0.0000 (0.0000–0.0000) 0.4022 (0.1193–0.6852)
cg06952798c 0.5428 (0.2146–0.8711) 0.0000 (0.0000–0.0000) 0.4572 (0.1289–0.7854) 0.5033 (0.0980–0.9086) 0.0000 (0.0000–0.0000) 0.4967 (0.0914–0.9020)
cg27483317a 0.7057 (0.4854–0.9261) 0.0000 (0.0000–0.0000) 0.2943 (0.0739–0.5146) 0.0000 (0.0000–0.0000) 0.5641 (0.2106–0.9176) 0.4359 (0.0824–0.7894)
cg09757049a 0.5358 (0.1247–0.9469) 0.0000 (0.0000–0.0000) 0.4642 (0.0531–0.8753) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg10215460a 0.5175 (0.2026–0.8324) 0.0000 (0.0000–0.0000) 0.4825 (0.1676–0.7974) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg14668152a 0.5124 (0.2010–0.8237) 0.0000 (0.0000–0.0000) 0.4876 (0.1763–0.7990) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg14273607a 0.4750 (0.0226–0.9275) 0.0000 (0.0000–0.0000) 0.5250 (0.0725–0.9774) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg06179303a 0.4279 (0.0041–0.8516) 0.0000 (0.0000–0.0000) 0.5721 (0.1484–0.9959) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg02792401b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.5255 (0.0644–0.9866) 0.0000 (0.0000–0.0000) 0.4745 (0.0134–0.9356)
  1. a,bRepresent significant CpG sites showing high heritability with 0 not included in the 2.5–97.5% confidence intervals in 1997 and 2007, respectively
  2. cRepresents overlapped significant CpG sites between 1997 and 2007
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