TY - JOUR AU - Wang, Lijie AU - Mohammadnejad, Afsaneh AU - Li, Weilong AU - Lund, Jesper AU - Li, Shuxia AU - Clemmensen, Signe AU - Timofeeva, Maria AU - Soerensen, Mette AU - Mengel-From, Jonas AU - Christensen, Kaare AU - Hjelmborg, Jacob AU - Tan, Qihua PY - 2021 DA - 2021/02/15 TI - Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins JO - Clinical Epigenetics SP - 35 VL - 13 IS - 1 AB - Epigenetic inactivation of O6-methylguanine DNA-methyltransferase (MGMT) is associated with increased sensitivity to alkylating chemotherapeutic agents in glioblastoma patients. The genetic background underlying MGMT gene methylation may explain individual differences in treatment response and provide a clue to a personalized treatment strategy. Making use of the longitudinal twin design, we aimed, for the first time, to estimate the genetic contributions to MGMT methylation in a Danish twin cohort. SN - 1868-7083 UR - https://doi.org/10.1186/s13148-021-01009-5 DO - 10.1186/s13148-021-01009-5 ID - Wang2021 ER -