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Fig. 2 | Clinical Epigenetics

Fig. 2

From: BRD4 inhibition alleviates mechanical stress-induced TMJ OA-like pathological changes and attenuates TREM1-mediated inflammatory response

Fig. 2

BRD4 inhibition can alleviate the expression of inflammatory factors induced by excessive mechanical stress and IL-1β. The concentration of JQ1 used in animal experiment is 50 μM. a qRT-PCR analysis of Tnf-α, Il-1β, and Il-6 in condylar cartilage at 14 days (n = 6). b Immunohistochemical analysis of TNF-α and IL-1β in condylar cartilage (200×) at 14 days (n = 12). TNF-α expressing and IL-1β expressing chondrocytes are denoted (arrow). c qRT-PCR analysis of Il-1β, Brd4, Il-6, Tnf-α in chondrocytes from samples treated as indicated. Error bars indicate the standard deviation (*P < 0.05; **P < 0.01)

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