Fig. 1

JQ1 can relieve the condylar cartilage thinning and subchondral bone resorption induced by overloading mechanical stress. a HE-stained sections (100×) of cartilage treated with 50 μM JQ1 at 14 days (n = 6). Scale bar indicates 100 μm. Cartilage thickness is indicated (black bar). FP indicates proliferative zone, T indicates transition zone, and H indicates hypertrophic zone. b Quantification of cartilage thickness of the samples shown in 1A (n = 6). Error bars indicate the standard deviation. (^##P < 0.01 vs MF group; **P < 0.01 vs control group). c Quantification of chondrocytes of the samples shown in 1A (n = 6). Error bars indicate the standard deviation (*P < 0.05; **P < 0.01). d Representative images showing trabecular architecture by micro-computed tomography (mCT) reconstruction in the subchondral bone. e mCT measurements for the indicated parameters in the subchondral bone. BV/TV, Tb.Th, Tb.N, and Tb.Sp were determined by mCT analysis (n = 8). Error bars indicate the standard deviation. (*P < 0.05; **P < 0.01). MF, mechanical force