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Fig. 4 | Clinical Epigenetics

Fig. 4

From: UHRF1 downregulation promotes T follicular helper cell differentiation by increasing BCL6 expression in SLE

Fig. 4

UHRF1 regulates the epigenetic modifications of the BCL6 promoter region. (a) The Schematic diagram showing the location of the P1, P2, and P3 regions in the BCL6 promoter for MeDIP-qPCR and ChIP-qPCR. (b) The levels of DNA methylation and H3K27me3 were downregulated in the induced Tfh cells with UHRF1-siRNA compared to the negative control. No significant changes in H3 acetylation levels were observed. (c) The levels of DNA methylation and H3K27me3 were upregulated in the induced Tfh cells with the UHRF1-lentivirus compared to the negative control. No significant change in H3 acetylation levels were observed. The values are the averages of at three biological replicates, and all data shown are the means ± SD. *P < 0.05, **P < 0.01 relative to control

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Clinical Epigenetics

ISSN: 1868-7083

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