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Fig. 3 | Clinical Epigenetics

Fig. 3

From: UHRF1 downregulation promotes T follicular helper cell differentiation by increasing BCL6 expression in SLE

Fig. 3

UHRF1 overexpression downregulates BCL6 expression and reduces Tfh cell differentiation. (a, b) Increased levels of UHRF1 mRNA (a) and protein (b) were observed in the cells transfected with UHRF1 overexpression compared to those with the empty control. (c, d) Flow cytometry results showed that the percentages of Tfh cells (c) and the MFI of BCL6 protein (d) were decreased in cells transfected with the UHRF1-lentivirus compared to the blank control. The values are the averages of at three biological replicates, and all data shown are the means ± SD. *P < 0.05, **P < 0.01 relative to control

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