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Fig. 2 | Clinical Epigenetics

Fig. 2

From: UHRF1 downregulation promotes T follicular helper cell differentiation by increasing BCL6 expression in SLE

Fig. 2

Knockdown of UHRF1 upregulates BCL6 expression and promotes Tfh cell differentiation in vitro. (a, b) The RT-qPCR results (a) and western blot results (b) showed that UHRF1 mRNA and protein levels were increased in the transfected cells with UHRF1-siRNA compared to the negative control. (c, d) Flow cytometry analysis showing that the percentage of Tfh cells (c) and the MFI of BCL6 protein (d) were increased in the transfected cells with UHRF1-siRNA compared to the negative control. The values are the averages of at least three biological replicates, and all data shown are the means ± SD. *P < 0.05, **P < 0.01 relative to control

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Clinical Epigenetics

ISSN: 1868-7083

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