Table 2 Sixteen CpGs associated with plasma copper in the genome-wide meta-analysis (p Value < 1 × 10−5)
CpG | Chr | Position | Gene | Relation to gene | Genome-wide meta-analysis of DNA methylation and plasma coppera | ||
|---|---|---|---|---|---|---|---|
Meta Z | p Value | FDR | |||||
cg25112191 | 1 | 151804260 | RORC; KIAA1026; TDRKH | 1stExon, 5′UTR; < 50 kb; < 50 kb | – 4.89 | 9.96 × 10–7 | 0.09 |
cg11023668 | 2 | 25095040 | ADCY3 | Body | – 4.45 | 8.68 × 10–6 | 0.23 |
cg20995564 | 2 | 145172035 | ZEB2 | Body | – 5.52 | 3.41 × 10–8 | 0.01 |
cg09480515 | 2 | 237033375 | AGAP1; GBX2 | 3′UTR; < 50 kb | – 4.47 | 7.75 × 10–6 | 0.22 |
cg21945842 | 3 | 105084992 | ALCAM | TSS1500 | – 4.51 | 6.48 × 10–6 | 0.22 |
cg24805089 | 5 | 176860947 | GRK6; DBN1; F12; PDLIM7; SLC34A1; PFN3; PRR7 | Body; < 50 kb; < 50 kb; < 50 kb; < 50 kb; < 50 kb; < 50 kb | – 4.55 | 5.39 × 10–6 | 0.22 |
cg21852842 | 7 | 1896827 | MAD1L1 | Body | – 4.55 | 5.47 × 10–6 | 0.22 |
cg18734877 | 8 | 27297419 | PTK2B; CHRNA2; EPHX2 | Body; < 50 kb; < 50 kb | – 4.52 | 6.33 × 10–6 | 0.22 |
cg07798295 | 16 | 89715839 | CHMP1A | Body | – 4.80 | 1.61 × 10–6 | 0.12 |
cg18608055 | 19 | 1130866 | SBNO2; GPX4; HMHA1 | Body; < 50 kb; < 50 kb | – 5.30 | 1.13 × 10–7 | 0.02 |
cg26470501 | 19 | 45252955 | BCL3 | Body | – 5.24 | 1.63 × 10–7 | 0.02 |
cg24263062 | 20 | 2730191 | EBF4; CPXM1 | Body; < 50 kb | 4.48 | 7.30 × 10–6 | 0.22 |
cg05825244 | 20 | 2730488 | EBF4; CPXM1 | Body; < 50 kb | 5.30 | 1.14 × 10–7 | 0.02 |
cg01523712 | 20 | 43437858 | RIMS4 | Body | 4.63 | 3.67 × 10–6 | 0.22 |
cg09349128 | 22 | 50327986 | ZBED4; ALG12; CRELD2; PIM3 | < 50 kb; < 50 kb; < 50 kb; < 50 kb | – 4.59 | 4.41 × 10–6 | 0.22 |
cg15376401 | X | 73438975 | NCRNA00182; MIR374B; MIR421 | Body; TSS1500; TSS1500 | 4.47 | 7.73 × 10–6 | 0.22 |