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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Genome-wide DNA methylation dynamics during epigenetic reprogramming in the porcine germline

Fig. 5

DNA methylation profile of the PMRs. Number of replicates: D28M (n = 1), D32M (n = 2), D36M (n = 2), D39M (n = 2), D42M (n = 1), D28F (n = 1), D32F (n = 2), D36F (n = 2), D39F (n = 2), D42F (n = 1). a Heatmap showing the levels of methylation of PMRs separated into their various genomic features. Each line corresponds to a single probe. b Line graphs representing the mean level of methylation for the same genomic features represented in a on each day. The upper panel corresponds to male PMRs and the lower panel to female PMRs. c Cumulative bar graph showing male and female genes located within the identified PMRs and their coincidence with PMRs in blastocyst [26] and oocyte and sperm [27]. Yellow section represents PMRs detected in all developmental stages. The lower panel shows the gene lists of genes located within PMRs throughout all developmental stages identified in male germ cells (left) and female germ cells (right). d Venn diagram showing genes containing PMRs in male and female PMRs. e Significantly enriched GO terms for persistently methylated genes in male (left panel, shown in blue) and female (right panel, shown in purple) germ cells

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