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Table 1 Main clinical and hematological characteristics of patients at diagnosis (n =75)

From: Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival

Variable

Median (range)

N (%) (n = 75)

Age, years

66 (32–83)

 

 < 65

 

34

 ≥ 65

 

41

Gender

  

 Male

 

52 (69)

 Female

 

23 (31)

Hemoglobin level, g/L

91 (57–136)

 

 < 100

 

50

 ≥ 100

 

25

Leukocyte count, × 109/L

2.9 (0.8–108)

 

 < 4

 

47

 > 4 and < 11

 

14

 ≥ 11

 

14

Platelet count, × 109/L

68 (5–536)

 

 < 100

 

48

 ≥ 100

 

27

Neutrophil count, × 109/L

1.23 (0.09–13.55)

 

 < 0.8

 

27

 ≥ 0.8

 

47

 No data

 

1

Blasts in PB, %

0 (0–74)

 

 < 5

 

55

 ≥ 5

 

20

Blasts in BM, %

15 (0–92)

 

 < 20

 

49

 ≥ 20

 

26

Cytogenetic

  

 Normal karyotype

 

28

 Abnormal karyotype

 

45

 Uninformative CC

 

2

Cytogenetic category (IPSS-R)

  

 Very good

 

1

 Good

 

30

 Intermediate

 

20

 Poor

 

6

 Very poor

 

16

 Uninformative CC

 

2

IPSS risk group (only MDS patients: 49)

  

 Intermediate-1

 

6

 Intermediate-2

 

23

 High

 

19

 No data

 

1

IPSS-R risk group (only MDS patients: 49)

  

 Low

 

1

 Intermediate

 

9

 High

 

16

 Very high

 

21

 No data

 

2

Treatment

  

 AZA

38

 

 Other treatment (ICE plus AZA and/or ASCT)

37

 
  1. PB peripheral blood, BM bone marrow, Uninformative CC cases with no metaphases, IPSS International Prognostic Score System, IPSS-R Revised IPSS, WHO World Health Organization, AZA azacitidine, ICE idarubicin, cytarabine and etoposide, ASCT allogeneic stem cell transplantation