TY - JOUR AU - Santini, V. AU - Kantarjian, H. M. AU - Issa, J. P. PY - 2001 DA - 2001// TI - Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications JO - Ann Intern Med VL - 134 UR - https://doi.org/10.7326/0003-4819-134-7-200104030-00011 DO - 10.7326/0003-4819-134-7-200104030-00011 ID - Santini2001 ER - TY - JOUR AU - Itzykson, R. AU - Fenaux, P. PY - 2014 DA - 2014// TI - Epigenetics of myelodysplastic syndromes JO - Leukemia VL - 28 UR - https://doi.org/10.1038/leu.2013.343 DO - 10.1038/leu.2013.343 ID - Itzykson2014 ER - TY - JOUR AU - Galm, O. AU - Herman, J. G. AU - Baylin, S. B. PY - 2006 DA - 2006// TI - The fundamental role of epigenetics in hematopoietic malignancies JO - Blood Rev VL - 20 UR - https://doi.org/10.1016/j.blre.2005.01.006 DO - 10.1016/j.blre.2005.01.006 ID - Galm2006 ER - TY - JOUR AU - Baylin, S. B. AU - Herman, J. G. AU - Graff, J. R. AU - Vertino, P. M. AU - Issa, J. P. PY - 1998 DA - 1998// TI - Alterations in DNA methylation: a fundamental aspect of neoplasia JO - Adv Cancer Res VL - 72 UR - https://doi.org/10.1016/S0065-230X(08)60702-2 DO - 10.1016/S0065-230X(08)60702-2 ID - Baylin1998 ER - TY - JOUR AU - Jones, P. AU - Baylin, S. PY - 2007 DA - 2007// TI - The epigenomics of cancer JO - Cell VL - 128 UR - https://doi.org/10.1016/j.cell.2007.01.029 DO - 10.1016/j.cell.2007.01.029 ID - Jones2007 ER - TY - JOUR AU - Portela, A. AU - Esteller, M. PY - 2010 DA - 2010// TI - Epigenetic modifications and human disease JO - Nat Biotechnol VL - 28 UR - https://doi.org/10.1038/nbt.1685 DO - 10.1038/nbt.1685 ID - Portela2010 ER - TY - JOUR AU - Baylin, S. B. PY - 2005 DA - 2005// TI - DNA methylation and gene silencing in cancer JO - Nat Clin Pract Oncol VL - 2 UR - https://doi.org/10.1038/ncponc0354 DO - 10.1038/ncponc0354 ID - Baylin2005 ER - TY - JOUR AU - Feinberg, A. P. AU - Vogelstein, B. PY - 1983 DA - 1983// TI - Hypomethylation of ras oncogenes in primary human cancers JO - Biochem Biophys Res Commun VL - 111 UR - https://doi.org/10.1016/S0006-291X(83)80115-6 DO - 10.1016/S0006-291X(83)80115-6 ID - Feinberg1983 ER - TY - JOUR AU - Chen, R. Z. AU - Pettersson, U. AU - Beard, C. AU - Jackson-Grusby, L. AU - Jaenisch, R. PY - 1998 DA - 1998// TI - DNA hypomethylation leads to elevated mutation rates JO - Nature VL - 395 UR - https://doi.org/10.1038/25779 DO - 10.1038/25779 ID - Chen1998 ER - TY - JOUR AU - Jones, P. A. AU - Laird, P. W. PY - 1999 DA - 1999// TI - Cancer epigenetics comes of age JO - Nat Genet VL - 21 UR - https://doi.org/10.1038/5947 DO - 10.1038/5947 ID - Jones1999 ER - TY - JOUR AU - Feinberg, A. P. AU - Tycko, B. PY - 2004 DA - 2004// TI - The history of cancer epigenetics JO - Nat Rev Cancer VL - 4 UR - https://doi.org/10.1038/nrc1279 DO - 10.1038/nrc1279 ID - Feinberg2004 ER - TY - JOUR AU - Jones, P. A. PY - 2002 DA - 2002// TI - DNA methylation and cancer JO - Oncogene VL - 21 UR - https://doi.org/10.1038/sj.onc.1205597 DO - 10.1038/sj.onc.1205597 ID - Jones2002 ER - TY - JOUR AU - Claus, R. AU - Lübbert, M. PY - 2003 DA - 2003// TI - Epigenetic targets in hematopoietic malignancies JO - Oncogene VL - 22 UR - https://doi.org/10.1038/sj.onc.1206814 DO - 10.1038/sj.onc.1206814 ID - Claus2003 ER - TY - JOUR AU - Diesch, J. AU - Zwick, A. AU - Garz, A. -. K. AU - Palau, A. AU - Buschbeck, M. AU - Götze, K. S. PY - 2016 DA - 2016// TI - A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers JO - Clin Epigenetics VL - 8 UR - https://doi.org/10.1186/s13148-016-0237-y DO - 10.1186/s13148-016-0237-y ID - Diesch2016 ER - TY - JOUR AU - Jones, P. A. AU - Issa, J. P. J. AU - Baylin, S. PY - 2016 DA - 2016// TI - Targeting the cancer epigenome for therapy JO - Nat Rev Genet VL - 17 UR - https://doi.org/10.1038/nrg.2016.93 DO - 10.1038/nrg.2016.93 ID - Jones2016 ER - TY - JOUR AU - Curik, N. AU - Burda, P. AU - Vargova, K. AU - Pospisil, V. AU - Belickova, M. AU - Vlckova, P. PY - 2012 DA - 2012// TI - 5-Azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU.1 gene and cell differentiation capacity JO - Leukemia VL - 26 UR - https://doi.org/10.1038/leu.2012.47 DO - 10.1038/leu.2012.47 ID - Curik2012 ER - TY - JOUR AU - Grövdal, M. AU - Karimi, M. AU - Tobiasson, M. AU - Reinius, L. AU - Jansson, M. AU - Ekwall, K. PY - 2014 DA - 2014// TI - Azacitidine induces profound genome-wide hypomethylation in primary myelodysplastic bone marrow cultures but may also reduce histone acetylation JO - Leukemia VL - 28 UR - https://doi.org/10.1038/leu.2013.265 DO - 10.1038/leu.2013.265 ID - Grövdal2014 ER - TY - JOUR AU - Chiappinelli, K. B. AU - Strissel, P. L. AU - Desrichard, A. AU - Li, H. AU - Henke, C. AU - Akman, B. PY - 2015 DA - 2015// TI - Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses JO - Cell VL - 162 UR - https://doi.org/10.1016/j.cell.2015.07.011 DO - 10.1016/j.cell.2015.07.011 ID - Chiappinelli2015 ER - TY - JOUR AU - Flotho, C. AU - Sommer, S. AU - Lübbert, M. PY - 2018 DA - 2018// TI - DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and juvenile myelomonocytic leukemia JO - Semin Cancer Biol VL - 51 UR - https://doi.org/10.1016/j.semcancer.2017.10.011 DO - 10.1016/j.semcancer.2017.10.011 ID - Flotho2018 ER - TY - JOUR AU - Tobiasson, M. AU - Abdulkadir, H. AU - Lennartsson, A. AU - Katayama, S. AU - Marabita, F. AU - Paepe, A. PY - 2017 DA - 2017// TI - Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease JO - Oncotarget VL - 8 UR - https://doi.org/10.18632/oncotarget.15807 DO - 10.18632/oncotarget.15807 ID - Tobiasson2017 ER - TY - JOUR AU - Issa, J. P. J. AU - Kantarjian, H. M. AU - Kirkpatrick, P. PY - 2005 DA - 2005// TI - Azacitidine JO - Nat Rev Drug Discov VL - 4 UR - https://doi.org/10.1038/nrd1698 DO - 10.1038/nrd1698 ID - Issa2005 ER - TY - JOUR AU - Navada, S. C. AU - Steinmann, J. AU - Lübbert, M. AU - Silverman, L. R. PY - 2014 DA - 2014// TI - Clinical development of demethylating agents in hematology JO - J Clin Investig VL - 124 UR - https://doi.org/10.1172/JCI69739 DO - 10.1172/JCI69739 ID - Navada2014 ER - TY - JOUR AU - Haferlach, T. AU - Nagata, Y. AU - Grossmann, V. AU - Okuno, Y. AU - Bacher, U. AU - Nagae, G. PY - 2014 DA - 2014// TI - Landscape of genetic lesions in 944 patients with myelodysplastic syndromes JO - Leukemia VL - 28 UR - https://doi.org/10.1038/leu.2013.336 DO - 10.1038/leu.2013.336 ID - Haferlach2014 ER - TY - JOUR AU - Yamazaki, J. AU - Issa, J. P. J. PY - 2013 DA - 2013// TI - Epigenetic aspects of MDS and its molecular targeted therapy JO - Int J Hematol VL - 97 UR - https://doi.org/10.1007/s12185-012-1197-4 DO - 10.1007/s12185-012-1197-4 ID - Yamazaki2013 ER - TY - JOUR AU - Mohammad, H. P. AU - Barbash, O. AU - Creasy, C. L. PY - 2019 DA - 2019// TI - Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer JO - Nat Med VL - 25 UR - https://doi.org/10.1038/s41591-019-0376-8 DO - 10.1038/s41591-019-0376-8 ID - Mohammad2019 ER - TY - JOUR AU - Papaemmanuil, E. AU - Gerstung, M. AU - Malcovati, L. AU - Tauro, S. AU - Gundem, G. AU - Loo, P. PY - 2013 DA - 2013// TI - Clinical and biological implications of driver mutations in myelodysplastic syndromes JO - Blood VL - 122 UR - https://doi.org/10.1182/blood-2013-08-518886 DO - 10.1182/blood-2013-08-518886 ID - Papaemmanuil2013 ER - TY - JOUR AU - Pellagatti, A. AU - Boultwood, J. PY - 2015 DA - 2015// TI - The molecular pathogenesis of the myelodysplastic syndromes JO - Eur J Haematol VL - 95 UR - https://doi.org/10.1111/ejh.12515 DO - 10.1111/ejh.12515 ID - Pellagatti2015 ER - TY - JOUR AU - Figueroa, M. E. AU - Skrabanek, L. AU - Li, Y. AU - Jiemjit, A. AU - Fandy, T. E. AU - Paietta, E. PY - 2009 DA - 2009// TI - MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation JO - Blood VL - 114 UR - https://doi.org/10.1182/blood-2009-01-200519 DO - 10.1182/blood-2009-01-200519 ID - Figueroa2009 ER - TY - JOUR AU - Issa, J. P. J. PY - 2013 DA - 2013// TI - The myelodysplastic syndrome as a prototypical epigenetic disease JO - Blood VL - 121 UR - https://doi.org/10.1182/blood-2013-02-451757 DO - 10.1182/blood-2013-02-451757 ID - Issa2013 ER - TY - JOUR AU - Jiang, Y. AU - Dunbar, A. AU - Gondek, L. P. AU - Mohan, S. AU - Rataul, M. AU - O’Keefe, C. PY - 2009 DA - 2009// TI - Aberrant DNA methylation is a dominant mechanism in MDS progression to AML JO - Blood VL - 113 UR - https://doi.org/10.1182/blood-2008-06-163246 DO - 10.1182/blood-2008-06-163246 ID - Jiang2009 ER - TY - JOUR AU - Scott, L. J. PY - 2016 DA - 2016// TI - Azacitidine: a review in myelodysplastic syndromes and acute myeloid leukaemia JO - Drugs VL - 76 UR - https://doi.org/10.1007/s40265-016-0585-0 DO - 10.1007/s40265-016-0585-0 ID - Scott2016 ER - TY - JOUR AU - Fenaux, P. AU - Mufti, G. J. AU - Hellstrom-Lindberg, E. AU - Santini, V. AU - Finelli, C. AU - Giagounidis, A. PY - 2009 DA - 2009// TI - Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study JO - Lancet Oncol VL - 10 UR - https://doi.org/10.1016/S1470-2045(09)70003-8 DO - 10.1016/S1470-2045(09)70003-8 ID - Fenaux2009 ER - TY - JOUR AU - Meldi, K. AU - Qin, T. AU - Buchi, F. AU - Droin, N. AU - Sotzen, J. AU - Micol, J. B. PY - 2015 DA - 2015// TI - Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia JO - J Clin Investig VL - 125 UR - https://doi.org/10.1172/JCI78752 DO - 10.1172/JCI78752 ID - Meldi2015 ER - TY - JOUR AU - Voso, M. T. AU - Fabiani, E. AU - Piciocchi, A. AU - Matteucci, C. AU - Brandimarte, L. AU - Finelli, C. PY - 2011 DA - 2011// TI - Role of BCL2L10 methylation and TET2 mutations in higher risk myelodysplastic syndromes treated with 5-Azacytidine JO - Leukemia VL - 25 UR - https://doi.org/10.1038/leu.2011.170 DO - 10.1038/leu.2011.170 ID - Voso2011 ER - TY - JOUR AU - Fandy, T. E. AU - Herman, J. G. AU - Kerns, P. AU - Jiemjit, A. AU - Sugar, E. A. AU - Choi, S. H. PY - 2009 DA - 2009// TI - Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies JO - Blood VL - 114 UR - https://doi.org/10.1182/blood-2009-02-203547 DO - 10.1182/blood-2009-02-203547 ID - Fandy2009 ER - TY - JOUR AU - Shen, L. AU - Kantarjian, H. AU - Guo, Y. AU - Lin, E. AU - Shan, J. AU - Huang, X. PY - 2010 DA - 2010// TI - DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes JO - J Clin Oncol VL - 28 UR - https://doi.org/10.1200/JCO.2009.23.4781 DO - 10.1200/JCO.2009.23.4781 ID - Shen2010 ER - TY - JOUR AU - Follo, M. Y. AU - Finelli, C. AU - Mongiorgi, S. AU - Clissa, C. AU - Bosi, C. AU - Testoni, N. PY - 2009 DA - 2009// TI - Reduction of phosphoinositide-phospholipase C beta1 methylation predicts the responsiveness to azacitidine in high-risk MDS JO - Proc Natl Acad Sci USA VL - 106 UR - https://doi.org/10.1073/pnas.0907109106 DO - 10.1073/pnas.0907109106 ID - Follo2009 ER - TY - JOUR AU - Cheson, B. D. AU - Greenberg, P. L. AU - Bennett, J. M. AU - Lowenberg, B. AU - Wijermans, P. W. AU - Nimer, S. D. PY - 2006 DA - 2006// TI - Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia JO - Blood VL - 108 UR - https://doi.org/10.1182/blood-2005-10-4149 DO - 10.1182/blood-2005-10-4149 ID - Cheson2006 ER - TY - JOUR AU - Reilly, B. AU - Tanaka, T. N. AU - Diep, D. AU - Yeerna, H. AU - Tamayo, P. AU - Zhang, K. PY - 2019 DA - 2019// TI - DNA methylation identifies genetically and prognostically distinct subtypes of myelodysplastic syndromes JO - Blood Adv VL - 3 UR - https://doi.org/10.1182/bloodadvances.2019000192 DO - 10.1182/bloodadvances.2019000192 ID - Reilly2019 ER - TY - JOUR AU - Römermann, D. AU - Hasemeier, B. AU - Metzig, K. AU - Göhring, G. AU - Schlegelberger, B. AU - Länger, F. PY - 2008 DA - 2008// TI - Global increase in DNA methylation in patients with myelodysplastic syndrome JO - Leukemia VL - 22 UR - https://doi.org/10.1038/leu.2008.76 DO - 10.1038/leu.2008.76 ID - Römermann2008 ER - TY - JOUR AU - Zahid, M. F. AU - Patnaik, M. M. AU - Gangat, N. AU - Hashmi, S. K. AU - Rizzieri, D. A. PY - 2016 DA - 2016// TI - Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy JO - Eur J Haematol VL - 97 UR - https://doi.org/10.1111/ejh.12771 DO - 10.1111/ejh.12771 ID - Zahid2016 ER - TY - JOUR AU - Chomienne, C. AU - Ballerini, P. AU - Balitrand, N. AU - Daniel, M. T. AU - Fenaux, P. AU - Castaigne, S. PY - 1990 DA - 1990// TI - All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship JO - Blood VL - 76 UR - https://doi.org/10.1182/blood.V76.9.1710.1710 DO - 10.1182/blood.V76.9.1710.1710 ID - Chomienne1990 ER - TY - JOUR AU - Vilhais-Neto, G. C. AU - Pourquié, O. PY - 2008 DA - 2008// TI - Retinoic acid JO - Curr Biol VL - 18 UR - https://doi.org/10.1016/j.cub.2007.12.042 DO - 10.1016/j.cub.2007.12.042 ID - Vilhais-Neto2008 ER - TY - JOUR AU - Belyaeva, O. V. AU - Korkina, O. V. AU - Stetsenko, A. V. AU - Kedishvili, N. Y. PY - 2008 DA - 2008// TI - Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity JO - FEBS J VL - 275 UR - https://doi.org/10.1111/j.1742-4658.2007.06184.x DO - 10.1111/j.1742-4658.2007.06184.x ID - Belyaeva2008 ER - TY - JOUR AU - Meschede, J. AU - Šadić, M. AU - Furthmann, N. AU - Miedema, T. AU - Sehr, D. A. AU - Müller-Rischart, A. K. PY - 2020 DA - 2020// TI - The Parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC JO - Sci Signal VL - 13 UR - https://doi.org/10.1126/scisignal.aav1256 DO - 10.1126/scisignal.aav1256 ID - Meschede2020 ER - TY - JOUR AU - Agirre, X. AU - Román-Gómez, J. AU - Vázquez, I. AU - Jiménez-Velasco, A. AU - Garate, L. AU - Montiel-Duarte, C. PY - 2006 DA - 2006// TI - Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia JO - Int J Cancer VL - 118 UR - https://doi.org/10.1002/ijc.21584 DO - 10.1002/ijc.21584 ID - Agirre2006 ER - TY - JOUR AU - Casals, N. AU - Zammit, V. AU - Herrero, L. AU - Fadó, R. AU - Rodríguez-Rodríguez, R. AU - Serra, D. PY - 2016 DA - 2016// TI - Carnitine palmitoyltransferase 1C: from cognition to cancer JO - Prog Lipid Res VL - 61 UR - https://doi.org/10.1016/j.plipres.2015.11.004 DO - 10.1016/j.plipres.2015.11.004 ID - Casals2016 ER - TY - STD TI - G & P biosciences. https://www.gnpbio.com. UR - https://www.gnpbio.com ID - ref48 ER - TY - JOUR AU - Zhang, C. AU - Zhao, H. AU - Li, J. AU - Liu, H. AU - Wang, F. AU - Wei, Y. PY - 2015 DA - 2015// TI - The identification of specific methylation patterns across different cancers JO - PLoS ONE VL - 10 ID - Zhang2015 ER - TY - STD TI - GeneCards the Human Gene Database [Internet]. https://www.genecards.org/. UR - https://www.genecards.org/ ID - ref50 ER - TY - JOUR AU - Gruet, M. AU - Cotton, D. AU - Coveney, C. AU - Boocock, D. J. AU - Wagner, S. AU - Komorowski, L. PY - 2020 DA - 2020// TI - β2-adrenergic signalling promotes cell migration by upregulating expression of the metastasis-associated molecule LYPD3 JO - Biology (Basel) VL - 9 ID - Gruet2020 ER - TY - JOUR AU - Tran, H. T. T. AU - Kim, H. N. H. -. J. AU - Lee, I. -. K. AU - Kim, Y. -. K. AU - Ahn, J. -. S. AU - Yang, D. -. H. PY - 2011 DA - 2011// TI - DNA methylation changes following 5-azacitidine treatment in patients with myelodysplastic syndrome JO - J Korean Med Sci VL - 26 UR - https://doi.org/10.3346/jkms.2011.26.2.207 DO - 10.3346/jkms.2011.26.2.207 ID - Tran2011 ER - TY - BOOK AU - Simons, A. AU - Shaffer, L. G. AU - Hastings, R. J. PY - 2013 DA - 2013// TI - Cytogenetic nomenclature: changes in the ISCN 2013 compared to the 2009 edition. Cytogenetic and Genome Research PB - Karger CY - Basel ID - Simons2013 ER - TY - JOUR AU - Sandoval, J. AU - Heyn, H. A. AU - Moran, S. AU - Serra-Musach, J. AU - Pujana, M. A. AU - Bibikova, M. PY - 2011 DA - 2011// TI - Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome JO - Epigenetics VL - 6 UR - https://doi.org/10.4161/epi.6.6.16196 DO - 10.4161/epi.6.6.16196 ID - Sandoval2011 ER - TY - JOUR AU - Assenov, Y. AU - Müller, F. AU - Lutsik, P. AU - Walter, J. AU - Lengauer, T. AU - Bock, C. PY - 2014 DA - 2014// TI - Comprehensive analysis of DNA methylation data with RnBeads JO - Nat Methods VL - 11 UR - https://doi.org/10.1038/nmeth.3115 DO - 10.1038/nmeth.3115 ID - Assenov2014 ER - TY - JOUR AU - Teschendorff, A. E. AU - Marabita, F. AU - Lechner, M. AU - Bartlett, T. AU - Tegner, J. AU - Gomez-Cabrero, D. PY - 2013 DA - 2013// TI - A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data JO - Bioinformatics VL - 29 UR - https://doi.org/10.1093/bioinformatics/bts680 DO - 10.1093/bioinformatics/bts680 ID - Teschendorff2013 ER - TY - JOUR AU - Ritchie, M. E. AU - Phipson, B. AU - Wu, D. AU - Hu, Y. AU - Law, C. W. AU - Shi, W. PY - 2015 DA - 2015// TI - Limma powers differential expression analyses for RNA-sequencing and microarray studies JO - Nucleic Acids Res VL - 43 UR - https://doi.org/10.1093/nar/gkv007 DO - 10.1093/nar/gkv007 ID - Ritchie2015 ER -