Table 3 Probes and genes associated with significantly differentially methylated regions found using bumphunter analysis for both obese and diabetic comparisons
From: Maternal diabetes and obesity influence the fetal epigenome in a largely Hispanic population
Gene ID | cg ID | Gene name | Function/pathway | Associated disorders/diseases | Gene location | Mean difference (M value) | P value | Comparison |
|---|---|---|---|---|---|---|---|---|
HOOK2 | cg06417478, cg04657146, cg11738485, cg23899408 | Hook Microtubule Tethering Protein 2 | Positioning or formation of aggresomes |  | Body | − 0.7415667 | 0.001 | Diabetic |
LCE3C | cg09972436 | Late Cornified Envelope 3C | Keratinization and developmental biology | Psoriatic arthritis | TSS1500 | − 0.8573606 | 0.04 | Diabetic |
TMEM63B | cg25069157 | Transmembrane Protein 63B | Osmosensitive calcium-permeable cation channel |  | Body | − 0.8412484 | 0.04 | Diabetic |
LTF | cg21787089, cg01427108 | Lactotransferrin | Regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis | Mastitis, kerato-conjunctivitis sicca, rheumatoid vasculitis, Clostridium difficile colitis, dental caries | Body | 0.6222828 | 0.016 | Obese |
DUSP22 | cg01516881, cg26668828 | Dual Specificity Phosphatase 22 | Activates the Jnk signaling pathway; dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase | Alk-negative anaplastic large cell lymphoma | Body | − 0.5737223 | 0.029 | Obese |
DUSP22 | cg18110333, cg05064044 | Dual Specificity Phosphatase 22 | Activates the Jnk signaling pathway; dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase | Alk-negative anaplastic large cell lymphoma | 1stExon; 5′UTR | − 0.5694813 | 0.03 | Obese |