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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Age-, tumor-, and metastatic tissue-associated DNA hypermethylation of a T-box brain 1 locus in human kidney tissue

Fig. 5

In silico analysis of association of CpG site methylation as reported by the TCGA-KIRC analysis with clinico-pathological parameters as well as recurrence-free survival (RFS) of patients in context with aggregated genomic organization of the TBR1 gene (TBR1), localization of CpG islands (CGI), annotated CpG sites (CpG), and pyrosequencing assay (PS). Plots show the logarithm of odds ratios (log(OR)) obtained in bivariate logistic regression analyses for association with state of metastasis, high-stage (T3 or T4) tumors, and high-grade (G2–3, G3 ) tumors for each CpG site amenable to statistical evaluation. Open circles indicate analyses exhibiting statistical significance (P < 0.01) following Bonferroni-Hochberg adjusting for multiple testing. Filled circles indicate that statistical significance has not been reached (P > 0.01). Recurrence-free survival analysis is presented by hazard ratios (HR) obtained in univariate Cox-regression analysis without adjustment for multiple testing

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