Fig. 5
Sensitivity analyses based on new defined DNAmAge groups (i.e. DNAmAge-ACC* and DNAmAge-DEC*) with a 5-year cut-off. Patients belonging to DNAmAge-ACC* group showed significantly favourable prognosis despite a OS or b PFS by Kaplan-Meier estimator with log-rank test. The DNAmAge-ACC* group was predicted to have a higher likelihood of responding to paclitaxel and gemcitabine than DNAmAge-DEC* group, which is shown in (c) and (d), respectively; DNAmAge-ACC* presented with significantly higher HPVpca scores and lower tumour mutation load than DNAmAge-DEC* group in (e) and (f), respectively. g Heatmap showing the differentially methylated probes (DMPs) that included a total of 246 stringent hypermethylated probes and 21 hypomethylated probes identified for DNAmAge-ACC* group. An immunoactivation phenotype was identified for DNAmAge-ACC* group due to the higher level of h immune enrichment score (IES) and i stromal enrichment score (SES) compared with the DNAmAge-DEC* group, and j dot plot showed immune-related GO terms and KEGG signalling pathways that were significantly enriched in DNAmAge-ACC* group