Skip to main content
Fig. 4 | Clinical Epigenetics

Fig. 4

From: Epigenetic age acceleration of cervical squamous cell carcinoma converged to human papillomavirus 16/18 expression, immunoactivation, and favourable prognosis

Fig. 4

Prognostic value of epigenetic age acceleration in CSCC. Patients belonging to DNAmAge-ACC showed significantly favourable prognosis despite of a OS or b PFS by Kaplan-Meier estimator with log-rank test. DNAm age was further discretized into quartiles: Q1 (4.8, 38.3), Q2 (38.3, 51.5), Q3 (51.5, 67.5), Q4 (67.5, 159), and rates of c OS and d PFS were also well distinguished. The association between epigenetic age acceleration and the prognosis of CSCC when adjusted for chronological age (binary) and tumour stage was presented with cubic spline graphs of the adjusted HR (solid red line) and 95% CI (dotted black line). Knots: − 33.5 (5th), − 4.1 (35th), 13.1 (65th), and 44.4 (95th) of the distribution of epigenetic age acceleration; Reference value 0, which means that DNAm age equals chronological age. Associations regarding OS and PFS are shown in (e) and (f), respectively

Back to article page