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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Epigenetic age acceleration of cervical squamous cell carcinoma converged to human papillomavirus 16/18 expression, immunoactivation, and favourable prognosis

Fig. 2

Molecular characteristics of two DNAm age groups. a Volcano plot of differentially expressed genes for DNAmAge-ACC group compared with the DNAmAge-DEC group with 103 upregulated and 184 downregulated genes. GSEA identified upregulated b lymphocyte-related pathways and c other immune-related signalling pathways. GSEA further identified upregulated d immune response functions and e other functions related to immunoactivation for DNAmAge-ACC group, whereas f BMP signalling pathway, serine/threonine kinase signalling pathway and Wnt signalling pathway were enriched for the DNAmAge-DEC group. There was a significantly higher presence of infiltrating immune/stromal cells but a lower tumour mutation load in the DNAmAge-ACC group compared with DNAmAge-DEC group, as shown in (g), (h), and (i), respectively. ES: enrichment scores; RES: running enrichment scores; RLM: ranked list metric. Two-tailed statistical P values were calculated by a two-sample Mann-Whitney test or Student’s t test when appropriate

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