Fig. 1
Correlations between DNAm age and chronological age and other molecular characteristics of DNAm age groups. a DNAm age of 200 mixed normal cervical samples predicts chronological age with a decent correlation coefficient, whereas such correlation was much weaker in 252 tumour samples from TCGA. b HPV oncoproteins E6 and E7 were highly correlated in 164 samples infected with two high-risk virus types—HPV16/18. The marginal rug line describes the distribution of the continuous variable at the corresponding coordinate axis. c DNAmAge-ACC group presented with significantly higher HPVpca scores than DNAmAge-DEC group and was inferred to be much more sensitive to two commonly used chemotherapy drugs, i.e. paclitaxel and gemcitabine, as shown in (d) and (e), respectively. The test for association between paired samples used Pearson’s correlation coefficient. Two-tailed statistical P values were calculated by a two-sample Mann-Whitney test or Student’s t test when appropriate