Table 4 Significant enrichment of GO terms in the top 500 sites from the Discovery Cohort EWAS of PTSD

GO:0032496: response to lipopolysaccharide

BP

6.97E − 06

0.042

PPARGC1A, CNR2, CPS1, TICAM1, ELANE, FGFR2, FOXP1, TICAM2, IL1B, MEF2C, ABCB4, PRKCE, ERBIN, HAMP, RARA, TFPI, VDR, CDC73, TNIP3

GO:0030374: ligand-dependent nuclear receptor transcription coactivator activity

MF

1.12E − 05

0.042

PPARGC1A, NCOA7, PPARG, PRKCB, RARA, RARB, RORA, VDR, MED12

GO:0002237:response to molecule of bacterial origin

BP

1.42E − 05

0.042

PPARGC1A, CNR2, CPS1, TICAM1, ELANE, FGFR2, FOXP1, TICAM2, IL1B, MEF2C, ABCB4, PRKCE, ERBIN, HAMP, RARA, TFPI, VDR, CDC73, TNIP3

GO:0071216: cellular response to biotic stimulus

BP

1.71E − 05

0.042

PPARGC1A, TICAM1, TICAM2, IL1B, MEF2C, ABCB4, PRKCE, HAMP, RARA, TFPI, VDR, WFS1, CDC73, TNIP3

GO:0003416: endochondral bone growth

BP

1.75E − 05

0.042

FGFR2, POC1A, MSX2, BNC2, RARA, RARB