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Table 2 Clinicopathological parameters of the 136 primary melanomas with known sentinel lymph node status

From: H3K27me3 and EZH2 expression in melanoma: relevance for melanoma progression and response to immune checkpoint blockade

  H3K27me3 +H3K27me3−p value
 n (%)n (%)n (%) 
Number13642 (30,9)94 (69,1) 
Age (years): median (range)59 (20-87)62 ( 22-84)58 (20-87) 
Gender
 Female60 (44.1)20 (33.3)40 (66.7)p = .583
 Male76 (55.9)23 (30.3)53 (69.7) 
Thickness: median
 < 1.0 mm24 (17.6)5 (20.8)19 (79.2) 
 1.01–2.0 mm61 (44.9)14 (23.0)47 (77.0)p = .033*
 2.01–4.0 mm32 (23.5)16 (50.0)16 (50.0) 
 > 4 mm19 (14.0)7 (36.8)12 (63.2) 
Histologic subtype
 Superficial spreading66 (48.5)21 (31.8)45 (68.2) 
 Nodular53 (39.0)17 (32.1)36 (67.9)p = .730
 Lentigious malignant2 (1.5)0 (0)2 (100) 
 Acral melanoma13 (9.6)4 (30.8)9 (69.2) 
 Other2 (1.5)0 (0)2 (100) 
Ulceration
 Positive56 (41.2)20 (35.7)36 (64.3)p = .308
 Negative80 (58.8)22 (27.5)58 (72.5) 
Sentinel lymph node status
 Positive32 (23.5)15 (46.9)17 (53.1)p = .025*
 Negative104 (76.5)27 (26.0)77 (74.0) 
Pigment
 Positive80 (58.8)29 (36.2)51 (63.8)p = .105
 Negative56 (41.2)13 (23.2)43 (76.8) 
Tumor-infiltrating lymphocytes
 Absent58 (42.6)17 (29.3)41 (70.7)p = .872
 Non-brisk18 (13.2)5 (27.8)13 (72.2) 
 Brisk60 (44.1)20 (33.3)40 (66.7) 
  1. Samples were analyzed for patient’s age, gender, tumor thickness, histologic subtype, presence of ulceration, sentinel lymph node status, and pigmentation. Tumor-infiltrating lymphocytes were assessed using the scoring system by Clark. Significance was determined by Χ2 test for categorical data (*p < 0.05)