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Table 1 The association of IGFBPL1 methylation and clinical factors in human ESCC

From: Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling

Clinical factorNumberIGFBPL1 methylation statusP value
Unmethylated n = 255 50.28%Methylated n = 246 49.10%
Age (years)   0.167
 < 63252136116 
 ≥ 63249119130 
Gender   0.102
 Male316152164 
 Female18510382 
Tumor size (cm)   0.009**
 < 4254144110 
 ≥ 4247111136 
Differentiation   0.518
 Well or moderate390200190 
 Poor1115556 
Lymph node metastasis   0.131
 Negative310166144 
 Positive19189102 
TNM stage   0.012*
 Stage I-II295164131 
 Stage III-VI20691115 
Distal metastasis   0.070
 Yes583622 
 No443219224 
Cancer embolus   0.848
 Yes1587 
 No486247239 
Smoking   0.277
 Yes271144127 
 No230111119 
Drinking   0.136
 Yes1165264 
 No385203182 
Inherited   0.806
 Yes1366868 
 No365187178 
  1. P values are obtained from chi-square test, significant difference
  2. *p < 0.05
  3. **p < 0.01