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Table 1 Baseline characteristics

From: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic and predictive biomarkers for coronary artery disease

 

Total (n = 167)

NCA (n = 56)

sCAD (n = 53)

AMI (n = 58)

P value

Demographic characteristics

Age

57.76 ± 11.80

54.23 ± 12.5

58.30 ± 11.41

60.67 ± 10.73

0.012

Gender/Male (%, M)

125 (74.9%)

35 (62.5%)

40 (75.5%)

50 (86.2%)

0.014

Clinical characteristics

BMI, kg/m2

25.18 ± 3.19

25.22 ± 2.70

25.01 ± 3.05

25.30 ± 3.76

0.889

Smoking (%, Y)

95 (56.9%)

17 (30.4%)

34 (64.2%)

44 (75.9%)

< 0.0001

Drinking (%, Y)

72 (43.1%)

15 (26.8%)

31 (58.5%)

26 (44.8%)

0.004

Diabetes mellitus (%, Y)

46 (27.5%)

4 (7.1%)

21 (39.6%)

21 (36.2%)

< 0.0001

Hyperlipemia (%, Y)

101 (60.5%)

20 (35.7%)

41 (77.4%)

40 (69.0%)

< 0.0001

Laboratory characteristics

Hemoglobin, g/L

134.68 ± 18.37

142.31 ± 16.84

134.26 ± 19.38

127.68 ± 16.11

< 0.0001

FBG, mmol/L

6.58 ± 2.61

5.35 ± 1.04

7.04 ± 2.60

7.34 ± 3.21

< 0.0001

HbA1c, %

6.30 ± 1.29

5.91 ± 0.87

6.55 ± 1.51

6.44 ± 1.34

0.019

Scr, μmol/L

83.59 ± 17.90

75.72 ± 16.22

87.21 ± 18.87

87.87 ± 16.23

< 0.0001

Uric acid, μmol/L

331.47 ± 86.72

324.13 ± 79.45

356.62 ± 86.68

315.58 ± 89.76

0.032

LDH, IU/L

276.64 ± 237.57

171.68 ± 37.18

188.83 ± 44.50

458.24 ± 331.19

< 0.0001

hsCRP, mg/L

3.86 ± 5.12

1.94 ± 2.41

2.78 ± 3.57

6.69 ± 6.81

< 0.0001

ALT, IU/L

35.04 ± 32.59

30.09 ± 30.37

35.64 ± 38.92

39.28 ± 27.91

0.320

AST, IU/L

55.25 ± 80.02

23.29 ± 13.74

25.998 ± 16.53

112.95 ± 114.11

< 0.0001

HDL-C, mmol/L

1.22 ± 1.15

1.19 ± 0.31

1.10 ± 0.35

1.36 ± 1.90

0.482

LDL-C, mmol/L

2.56 ± 0.97

2.79 ± 0.87

2.48 ± 1.09

2.42 ± 0.91

0.093

TC, mmol/L

4.29 ± 1.16

4.62 ± 0.92

4.07 ± 1.37

4.17 ± 1.09

0.029

TG, mmol/L

2.12 ± 5.98

1.83 ± 1.19

1.76 ± 0.88

2.73 ± 10.08

0.635

NT-proBNP, pg/mL

496.40 ± 1504.93

86.25 ± 221.68

224.41 ± 396.73

1140.94 ± 2397.50

< 0.0001

CK, IU/L

372.70 ± 659.52

99.80 ± 57.03

118.38 ± 134.82

868.59 ± 929.25

< 0.0001

cTnI, ng/mL

8.64 ± 20.38

0.15 ± 0.30

0.89 ± 2.94

23.92 ± 28.94

< 0.0001

MYO, ng/mL

256.08 ± 572.39

28.26 ± 11.63

48.63 ± 47.83

665.59 ± 830.84

< 0.0001

CK-MB, ng/mL

34.05 ± 65.07

3.42 ± 4.95

7.06 ± 21.94

88.30 ± 85.29

< 0.0001

  1. Data are means ± SD or number (percentage) of subjects. BMI body mass index, FBG fasting blood glucose, HbA1c hemoglobin A1c, Scr serum creatinine, LDH lactate dehydrogenase, hsCRP hypersensitive C-reactive protein, ALT alanine aminotransferase, AST aspartate transaminase, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TC total cholesterol, TG triglycerides, NT-proBNP N-terminal pro-brain natriuretic peptide, CK creatine kinase, cTnI cardiac troponin I, MYO myoglobin, CK-MB MB isoenzyme of creatine kinase, NCA normal coronary artery, sCAD stable coronary artery disease, AMI acute myocardial infarction. The chi-squared test was used for comparison of categorical variables and one-way analysis of variance (one-way ANOVA) was used for continuous variables. The P value<0.05 was regarded as statistically significant