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Fig. 1 | Clinical Epigenetics

Fig. 1

From: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic and predictive biomarkers for coronary artery disease

Fig. 1

Genome-wide distribution of 5hmC in plasma samples of sCAD, AMI patients, and NCA individuals. a Metagene profiles of cell free 5hmC in NCA, sCAD and AMI samples. b The pie chart shows the overall genomic distribution of hMRs in cfDNA. c Normalized enrichment score of hMRs across distinct genomic regions relative to that expected in NCA, sCAD, and AMI samples, with positive values indicating enriched more than expected. d Principle component analysis (PCA) plot of 5hmC FPKM in cfDNA from CAD (AMI + sCAD) and NCA samples. e Heatmap of the top 200 potential 5hmC markers in CAD and NCA groups. Unsupervised hierarchical clustering was performed across genes and samples. CAD coronary artery disease, NCA normal coronary artery, AMI acute myocardial infarction, sCAD stable coronary artery disease, TSS transcription start site, TTS transcription termination site, FPKM fragments per kilobase of transcript per million mapped reads

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Clinical Epigenetics

ISSN: 1868-7083

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