Skip to main content

Table 2 Univariate cox analysis for progression-free survival and overall survival for pediatric EPN_PF

From: Characterization of global 5-hydroxymethylcytosine in pediatric posterior fossa ependymoma

  Progression-free survival Overall survival
Variable Hazard ratio 95% CI P value Hazard ratio 95% CI P value
Mo. subgroup (EPN_PFA vs. EPN_PFB) 8.012 1.815–35.371 0.006 10.854 1.446–81.465 0.020
5hmC subgroup (high vs. low) 3.438 1.367–8.646 0.009 3.030 1.192–7.702 0.020
Resection (STR vs. GTR) 1.338 0.602–2.972 0.475 1.445 0.634–3.292 0.381
Ki-67 index (≥ 20% vs. < 20%) 3.726 1.475–9.427 0.005 1.787 0.921–3.468 0.086
1q gain (yes vs. no) 2.666 1.086–6.548 0.032 3.148 1.283–7.722 0.012
Age, years (< 4 vs. 4–18) 1.567 0.678–3.618 0.293 1.376 0.580–3.262 0.469
Radiotherapy (yes vs. no) 0.695 0.281–1.717 0.430 0.477 0.197–1.159 0.102
Chemotherapy (yes vs. no) 0.839 0.334–2.112 0.710 0.226 0.052–0.985 0.053
Histology (WHO III vs. WHO II) 2.115 0.760–5.885 0.151 2.938 0.855–10.104 0.087
Gender (male vs. female) 1.416 0.530–3.783 0.487 1.015 0.400–2.577 0.975
  1. P values in italics are of statistical significance
  2. Abbreviations: Mo. molecular, PF posterior fossa, STR subtotal resection, GTR gross total resection, EPN_PFA Group A posterior fossa ependymoma, EPN_PFB Group B posterior fossa ependymoma