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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer

Fig. 4

Functional network analysis of I-MDSCs in CRC microenvironment. The significantly upregulated genes in TT, compared with NT from 2 patients were uploaded in DAVID to identify the biological pathways. BioCarta pathway of IL-6 signaling pathway is identified in the enrichment analysis with significant enrichment of upregulated genes with P < 0.05 (a). WNT signaling is the top KEGG pathway regulated in I-MDSCs, compared with APCs within the TME (b). The black ovals highlight the KEGG identified functional pathways that are regulated by I-MDSCs, within the TME. The red highlights without boxes show the functional consequences of related genes

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