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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer

Fig. 3

Differential gene expression of I-MDSCs in CRC microenvironment. Hierarchical clustering of I-MDSCs from two TT and NT (from patients #07 and 08) on differentially expressed RNA transcripts from RNA-Seq data. Each column represents a sample and each row represents a transcript. Expression level of each gene in a single sample is depicted according to color scale (a). Functional categorization of both upregulated and downregulated top significantly affected transcripts (P value < 0.05) from CLC analysis were analyzed through DAVID separately. The total number of genes come under both downregulated and upregulated categories was used to calculate the percentage of genes come under individual functional category. The bar diagram shows the percentage of genes present in each functional category (b). Heat maps show the log2 of transcript per million (TPM) representing fold change relative to the mean expression of HDAC activation and transcriptional silence, DNA methylation, and chromatin silencing and histone acetylation in TT, compared with NT (c)

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