A DNA methylation signature to improve survival prediction of gastric cancer

Clinical Epigenetics

Table 2 Correlations between clinical characteristics and risk score derived from the DNA methylation signature

Variable	N	High risk	Low risk	P value
Age (years)	363			0.051
≥ 60	185	93	92
< 60	96	52	44
Gender	363			0.000*
Male	241	136	105
Female	122	45	77
Race	330			0.106
White	235	108	127
Non-white	95	53	42
Family history	315			1.000
Yes	17	9	8
No	298	150	148
H. pylori infection	177			1.000
Positive	20	9	11
Negative	157	70	87
Tumor location	362			0.183
Cardia region (Cardia + GEJ)	91	51	40
Non-cardia region	271	130	141
Grade	354			0.380
G3	221	112	109
G1 + G2	133	61	72
T stage	363			0.562
T3+T4	274	139	135
T1+T2	89	42	47
N stage	355			0.463
N1 + N2 + N3	243	123	120
N0	112	52	60
M stage	350			0.176
M1	21	14	7
M0	329	161	168
TNM stage	349			0.954
III + IV	186	93	93
I + II	163	82	81
Recurrence	363			0.014*
Yes	126	74	52
No	237	107	130

P values were acquired by chi-square test or Fisher’s test. *P value < 0.05 was considered statistically significant. GEJ gastro-esophageal junction

ISSN: 1868-7083