Fig. 4From: A DNA methylation signature to improve survival prediction of gastric cancerThe DNA methylation signature is associated with cancer recurrence. a The distribution of cancer recurrence status in the high-risk and low-risk subgroup. The difference between the two subgroups was determined by chi-square test. b Box plot of risk score of patients with or without cancer recurrence. T test was used to determine the significance of the comparison. c The multivariate Cox regression analysis performed on 345 gastric cancer (GC) patients that contained age, gender, tumor grade, cancer recurrence, TNM stage, and risk score as covariates. Risk score and age were evaluated as continuous variables, and gender, tumor grade, cancer recurrence, and TNM stage were evaluated as category variables. Orange solid dots represent the hazard ratio (HR) of death and open-ended horizontal lines represent the 95% confidence intervals (CIs). All P values were calculated using Cox proportional hazards analysis. d Kaplan-Meier estimate of the overall survival of the entire set GC patients (N = 345) using the DNA methylation signature. GC patients were stratified by cancer recurrence status and the high-risk or low-risk subgroup of patients was determined on the basis of the median risk score. e Kaplan-Meier curves for GC patients without cancer recurrence (N = 226). f Kaplan-Meier curves for patients with cancer recurrence (N = 119). The differences between the survival curves were determined by the two-sided log-rank testBack to article page