Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer

Table 4 Predictors of test positivity (any marker detected) in cases without neoplasia

Predictor	Odds ratio^a	95% CI	p value
Gender (male)	1.57	0.97–2.59	0.072
Log(ccfDNA Yield)	1.89	1.30–2.75	0.0008
50–59 years of age	1.00	0.35–3.29	0.993
60–69 years of age	1.97	0.74–6.25	0.206
70–79 years of age	2.30	0.84–7.47	0.128
Over 80 years of age	3.82	0.69–18.40	0.098
Colorectal non-neoplastic pathologies^b	1.26	0.65–2.45	0.492
Other comorbidities^c	1.50	0.84–2.72	0.170

^aOdds ratios are estimated for each covariate independently. 95% confidence intervals are shown for odds ratio
^bBenign polyps (hyperplastic, unspecified, inflammatory, other polyps), inflammatory bowel disease, diverticular disease, angiodysplasia, hemorrhoids
^cHypertension, diabetes, asthma, chronic ischemia, angina pectoris, atherosclerosis, cerebral infarction, myocardial infarction, rheumatoid arthritis, chronic obstructive pulmonary disease

ISSN: 1868-7083